Introduction: Over the past decades, neuroimaging studies have clarified that a significant
proportion of patients with sickle cell disease (SCD) have functionally significant brain …

Conclusion Patients with SCD suffer from a host of neurologic complications of their disease,
including cognitive dysfunction in the absence of concomitant stroke. While the …

Background: Sickle cell disease (SCD) is an autosomal recessive hemolytic disorder; its
cerebrovascular complications include silent cerebral ischemia, infarct, and brain atrophy …

Silent cerebral infarcts and arteriopathy are common and progressive in individuals with
sickle cell anemia. However, most data describing brain lesions in sickle cell anemia are …

Background: Individuals with sickle cell anemia have heightened risk of stroke and cognitive
dysfunction. Given its high prevalence globally, whether sickle cell trait (SCT) is a risk factor …

Sickle cell disease (SCD) is the most common genetic blood disorder, characterized by red
cell hemolysis, anemia, and corresponding increased compensatory cerebral blood flow …

Background: Patients with sickle cell anemia (SCA) are at a high risk to develop cerebral
damage. Most common are silent cerebral infarctions (SCIs), visible as white matter …

Sickle cell anemia (SCA) is a well-characterized monogenetic disorder with a high
prevalence of cerebral vasculopathy, silent cerebral infarcts, and strokes. A significant …

Conventional MRI (cMRI) has shown that brain abnormalities without clinical stroke can
manifest in patients with sickle cell disease (SCD). We used quantitative MRI (qMRI) and …

Objective Sickle cell disease (SCD) is associated with cerebrovascular disease, cerebral
infarction, and cognitive dysfunction. This study aimed to detect the presence and extent of …