Bidirectional regulation role of PARP-1 in high glucose-induced endothelial injury
Y Zhang, W Wang - Experimental Cell Research, 2022 - Elsevier
Loss of poly (ADP-ribose) polymerase-1 (PARP-1) has been found to slow the progression
of diabetes and diabetic angiopathy. In our study, we found bidirectional regulation of PARP …
of diabetes and diabetic angiopathy. In our study, we found bidirectional regulation of PARP …
Poly (ADP-ribose) polymerase 1 inhibition improves coronary arteriole function in type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is associated with microvascular dysfunction. We
hypothesized that increased poly (ADP-ribose) polymerase 1 (PARP-1) activity contributes …
hypothesized that increased poly (ADP-ribose) polymerase 1 (PARP-1) activity contributes …
Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly (ADP-ribose) polymerase activation
Peroxynitrite and hydroxyl radicals are potent initiators of DNA single-strand breakage,
which is an obligatory stimulus for the activation of the nuclear enzyme poly (ADP ribose) …
which is an obligatory stimulus for the activation of the nuclear enzyme poly (ADP ribose) …
Establishment of an immortalized PARP‐1−/− murine endothelial cell line: A new tool to study PARP‐1 mediated endothelial cell dysfunction
A Carrillo, Y Monreal, P Ramirez… - Journal of Cellular …, 2005 - Wiley Online Library
Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) plays a critical role in endothelial cell
dysfunction associated with various pathophysiological conditions. To elucidate PARP-1 …
dysfunction associated with various pathophysiological conditions. To elucidate PARP-1 …
Role of poly (ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme
Hyperglycemia-induced overproduction of superoxide by mitochondrial electron-transport
chain triggers several pathways of injury involved in the pathogenesis of diabetic …
chain triggers several pathways of injury involved in the pathogenesis of diabetic …
[HTML][HTML] Poly-ADP-ribose polymerase inhibition enhances ischemic and diabetic wound healing by promoting angiogenesis
X Zhou, D Patel, S Sen, V Shanmugam… - Journal of vascular …, 2017 - Elsevier
Objective Chronic nonhealing wounds are a major health problem for patients in the United
States and worldwide. Diabetes and ischemia are two major risk factors behind impaired …
States and worldwide. Diabetes and ischemia are two major risk factors behind impaired …
Role of poly (ADP-ribose) polymerase activation in the pathogenesis of diabetes mellitus and diabetic vascular dysfunction
Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Diabetes Mellitus and
Diabetic Vascular Dysfunction Page 1 277 0-8493-0073-8/02/$0.00+$1.50 © 2002 by CRC …
Diabetic Vascular Dysfunction Page 1 277 0-8493-0073-8/02/$0.00+$1.50 © 2002 by CRC …
Poly (ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-κB
The current study investigated the role of poly (ADP-ribose) polymerase (PARP) in the
development of diabetic retinopathy. Activity of PARP was increased in whole retina and in …
development of diabetic retinopathy. Activity of PARP was increased in whole retina and in …
Protective Effects of PARP-1 Knockout on Dyslipidemia-Induced Autonomic and Vascular Dysfunction in ApoE−/− Mice: Effects on eNOS and Oxidative Stress
The aims of this study were to investigate the role of poly (ADP-ribose) polymerase (PARP)-
1 in dyslipidemia-associated vascular dysfunction as well as autonomic nervous system …
1 in dyslipidemia-associated vascular dysfunction as well as autonomic nervous system …
PAR-2 mediates increased inflammatory cell adhesion and neointima formation following vascular injury in the mouse
GM Tennant, RM Wadsworth, S Kennedy - Atherosclerosis, 2008 - Elsevier
Activation of PAR-2 in the vasculature affects vascular tone and adhesion of leukocytes to
the endothelium. Since adhesion of leukocytes is increased following vascular injury and is …
the endothelium. Since adhesion of leukocytes is increased following vascular injury and is …