Bipolar oscillations between positive and negative mood states in a computational model of Basal Ganglia

PP Balasubramani, VS Chakravarthy - Cognitive Neurodynamics, 2020 - Springer
Bipolar disorder is characterized by mood swings—oscillations between manic and
depressive states. The swings (oscillations) mark the length of an episode in a patient's …

[HTML][HTML] A dynamical bifurcation model of bipolar disorder based on learned expectation and asymmetry in mood sensitivity

SS Chang, T Chou - Computational Psychiatry (Cambridge, Mass.), 2018 - ncbi.nlm.nih.gov
Bipolar disorder is a common psychiatric dysfunction characterized by recurring episodes of
mania and depression. Despite its prevalence, the causes and mechanisms of bipolar …

Bipolar disorder: a neural network perspective on a disorder of emotion and motivation

M Wessa, P Kanske, J Linke - Restorative Neurology and …, 2014 - content.iospress.com
Bipolar disorder (BD) is a severe, chronic disease with a heritability of 60–80%. BD is
frequently misdiagnosed due to phenomenological overlap with other psychopathologies …

A unified model of the pathophysiology of bipolar disorder

P Magioncalda, M Martino - Molecular Psychiatry, 2022 - nature.com
This work provides an overview of the most consistent alterations in bipolar disorder (BD),
attempting to unify them in an internally coherent working model of the pathophysiology of …

Origin of cyclicity in bipolar disorders: a computational approach

A Goldbeter - Pharmacopsychiatry, 2013 - thieme-connect.com
Bipolar disorders are characterized by the spontaneous, recurrent alternation of episodes of
mania and depression. To investigate the type of mechanism capable of accounting for the …

The functional neuroanatomy of bipolar disorder: a consensus model

SM Strakowski, CM Adler, J Almeida… - Bipolar …, 2012 - Wiley Online Library
Strakowski SM, Adler CM, Almeida J, Altshuler LL, Blumberg HP, Chang KD, DelBello MP,
Frangou S, McIntosh A, Phillips ML, Sussman JE, Townsend JD. The functional …

Bipolar disorder dynamics: affective instabilities, relaxation oscillations and noise

MB Bonsall, JR Geddes… - Journal of the Royal …, 2015 - royalsocietypublishing.org
Bipolar disorder is a chronic, recurrent mental illness characterized by extreme episodes of
depressed and manic mood, interspersed with less severe but highly variable mood …

[HTML][HTML] A critical evaluation of dynamical systems models of bipolar disorder

A Nunes, S Singh, J Allman, S Becker, A Ortiz… - Translational …, 2022 - nature.com
Bipolar disorder (BD) is a mood disorder involving recurring (hypo) manic and depressive
episodes. The inherently temporal nature of BD has inspired its conceptualization using …

Modeling and analysis of mood dynamics in the bipolar spectrum

HG Villasanti, KM Passino - IEEE Transactions on …, 2020 - ieeexplore.ieee.org
This article introduces a nonlinear ordinary differential equation model of mood dynamics for
disorders on the bipolar spectrum. Motivated by biopsychosocial findings, the model …

[HTML][HTML] An emotional-response model of bipolar disorders integrating recent findings on amygdala circuits

M Bigot, M Alonso, J Houenou, S Sarrazin… - Neuroscience & …, 2020 - Elsevier
Because of our classification system limitations for defining psychiatric disorders and
understanding their physiopathology, a new research area based on dimensions has …