The observation and analysis of intra-tumour heterogeneity (ITH), particularly in genomic
studies, has advanced our understanding of the evolutionary forces that shape cancer …

As tumors accumulate genetic alterations, an evolutionary process occurs in which
genetically distinct subclonal populations of cells co-exist, resulting in intratumor genetic …

Precision medicine requires an understanding of cancer genes and mutational processes,
as well as an appreciation of the extent to which these are found heterogeneously in cancer …

Recent technologic advances have permitted higher resolution and more rapid analysis of
individual cancer genomes at the single-nucleotide level. Such advances have shown …

The population of cells that make up a cancer are manifestly heterogeneous at the genetic,
epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra …

Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer
medicine. Here, we review data and technologies that have revealed intra-tumor …

Cancer patients die primarily due to disease recurrence after transient treatment responses.
The emergence of therapy‐resistant escape variants is fuelled by intra‐tumour …

Impacts of genetic and non-genetic intra-tumor heterogeneity (ITH) on tumor phenotypes
and evolvability remain debated. We analyze ITH in lung squamous cell carcinoma at the …

Investigation into intratumoral heterogeneity (ITH) of the epigenome is in a formative stage.
The patterns of tumor evolution inferred from epigenetic ITH and genetic ITH are remarkably …

Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …