High Titer of (S)-Equol Synthesis from Daidzein in Escherichia coli
H Deng, S Gao, W Zhang, T Zhang, N Li… - ACS Synthetic …, 2022 - ACS Publications
(S)-Equol is the terminal metabolite of daidzein and plays important roles in human health.
However, due to anaerobic inefficiency, limited productivity in (S)-equol-producing strains …
However, due to anaerobic inefficiency, limited productivity in (S)-equol-producing strains …
Characterization and Identification of a New Daidzein Reductase Involved in (S)-Equol Biosynthesis in Clostridium sp. ZJ6
Y Hu, C Yang, C Song, W Zhong, B Li, L Cao… - Frontiers in …, 2022 - frontiersin.org
(S)-equol (EQ) is an isoflavone with high estrogen-like activity in the human body, and is
only produced by some gut bacteria in vivo. It plays an important role in maintaining …
only produced by some gut bacteria in vivo. It plays an important role in maintaining …
To Construct an Engineered (S)-Equol Resistant E. coli for in Vitro (S)-Equol Production
H Li, S Mao, H Chen, L Zhu, W Liu, X Wang… - Frontiers in …, 2018 - frontiersin.org
(S)-equol is one of the major metabolites of daidzein that is produced by human and animal
gut bacteria. Most of the physiological functions of soybean isoflavones, such as anti …
gut bacteria. Most of the physiological functions of soybean isoflavones, such as anti …
P212A Mutant of Dihydrodaidzein Reductase Enhances (S)-Equol Production and Enantioselectivity in a Recombinant Escherichia coli Whole-Cell Reaction System
ABSTRACT (S)-Equol, a gut bacterial isoflavone derivative, has drawn great attention
because of its potent use for relieving female postmenopausal symptoms and preventing …
because of its potent use for relieving female postmenopausal symptoms and preventing …
Biosynthesis of (S)-Equol from Soy Whey by Metabolically Engineered Escherichia coli
Z Wang, X Li, F Azi, Y Dai, Z Xu, L Yu… - Journal of Agricultural …, 2023 - ACS Publications
(S)-Equol is one of the most bioactive metabolites of the isoflavones with immense
nutritional and pharmaceutical value. Soy whey is the major liquid byproduct of the soy …
nutritional and pharmaceutical value. Soy whey is the major liquid byproduct of the soy …
The production of S-equol from daidzein is associated with a cluster of three genes in Eggerthella sp. YY7918
Y Kawada, S Yokoyama, E Yanase, T Niwa… - … of microbiota, food …, 2016 - jstage.jst.go.jp
Daidzein (DZN) is converted to equol (EQL) by intestinal bacteria. We previously reported
that Eggerthella sp. YY7918, which is found in human feces, is an EQL-producing bacterium …
that Eggerthella sp. YY7918, which is found in human feces, is an EQL-producing bacterium …
Polymeric solvent engineering for gram/liter scale production of a water-insoluble isoflavone derivative, (S)-equol
Abstract A potent phytoestrogen,(S)-equol, is a promising isoflavone derivative drawing our
great attention owing to its various biological and clinical benefits. Through selective …
great attention owing to its various biological and clinical benefits. Through selective …
Advances in exploring equol production and application
BJ Li - Journal of food processing and preservation, 2019 - Wiley Online Library
The soybean isoflavone daidzein has been extensively studied. Equol represents the main
active metabolite of daidzein in vivo. Due to its broadly biological activities, the preparation …
active metabolite of daidzein in vivo. Due to its broadly biological activities, the preparation …
Identification of a novel dihydrodaidzein racemase essential for biosynthesis of equol from daidzein in Lactococcus sp. strain 20-92
Y Shimada, M Takahashi, N Miyazawa… - Applied and …, 2012 - Am Soc Microbiol
Equol is metabolized from daidzein, a soy isoflavone, by the gut microflora. In this study, we
identified a novel dihydrodaidzein racemase (l-DDRC) that is involved in equol biosynthesis …
identified a novel dihydrodaidzein racemase (l-DDRC) that is involved in equol biosynthesis …
Daidzein reductase of Eggerthella sp. YY7918, its octameric subunit structure containing FMN/FAD/4Fe-4S, and its enantioselective production of R …
Y Kawada, T Goshima, R Sawamura… - Journal of bioscience …, 2018 - Elsevier
S-Equol is a metabolite of daidzein, a type of soy isoflavone, and three reductases are
involved in the conversion of daidzein by specific intestinal bacteria. S-Equol is thought to …
involved in the conversion of daidzein by specific intestinal bacteria. S-Equol is thought to …