Heterologous expression of equol biosynthesis genes from Adlercreutzia equolifaciens

L Vázquez, AB Flórez, J Rodríguez… - FEMS Microbiology …, 2021 - academic.oup.com
Equol is the isoflavone-derived metabolite with the greatest estrogenic and antioxidant
activity. It is produced from daidzein by fastidious and oxygen-susceptible intestinal bacteria …

Isolation and identification of a human intestinal bacterium capable of daidzein conversion

Y Guo, L Zhao, X Fang, Q Zhong, H Liang… - FEMS Microbiology …, 2021 - academic.oup.com
Equol, which produced from daidzein (one of the principal isoflavones), is recognized to be
the most resultful in stimulating an estrogenic and antioxidant response. The daidzein …

[HTML][HTML] Highly efficient enzymatic preparation of daidzein in deep eutectic solvents

QB Cheng, LW Zhang - Molecules, 2017 - mdpi.com
Daidzein, which is scarce in nature, has gained significant attention due to its superior
biological activity and bioavailability compared with daidzin. So far, it has been widely used …

Enantioselective Synthesis of S-Equol from Dihydrodaidzein by a Newly Isolated Anaerobic Human Intestinal Bacterium

XL Wang, HG Hur, JH Lee, KT Kim… - Applied and …, 2005 - Am Soc Microbiol
ABSTRACT A newly isolated rod-shaped, gram-negative anaerobic bacterium from human
feces, named Julong 732, was found to be capable of metabolizing the isoflavone …

Cloning and expression of a novel NADP (H)-dependent daidzein reductase, an enzyme involved in the metabolism of daidzein, from equol-producing Lactococcus …

Y Shimada, S Yasuda, M Takahashi… - Applied and …, 2010 - Am Soc Microbiol
Equol is a metabolite produced from daidzein by enteric microflora, and it has attracted a
great deal of attention because of its protective or ameliorative ability against several sex …

Identification of an enzyme system for daidzein-to-equol conversion in Slackia sp. strain NATTS

H Tsuji, K Moriyama, K Nomoto… - Applied and …, 2012 - Am Soc Microbiol
An Escherichia coli library comprising 8,424 strains incorporating gene fragments of the
equol-producing bacterium Slackia sp. strain NATTS was constructed and screened for E …

Stereospecific Biotransformation of Dihydrodaidzein into (3S)-Equol by the Human Intestinal Bacterium Eggerthella Strain Julong 732

M Kim, SI Kim, J Han, XL Wang… - Applied and …, 2009 - Am Soc Microbiol
Stereochemical course of isoflavanone dihydrodaidzein (DHD) reduction into the isoflavan
(3 S)-equol via tetrahydrodaidzein (THD) by the human intestinal anaerobic bacterium …

Identification of two novel reductases involved in equol biosynthesis in Lactococcus strain 20–92

Y Shimada, M Takahashi, N Miyazawa… - Journal of molecular …, 2012 - karger.com
Lactococcus strain 20–92 is a bacterium that produces equol directly from daidzein under
anaerobic conditions. In this study, we reveal that the transcription of the gene encoding …

Application of recombinant lactic acid bacteria and bifidobacteria able to enrich soy beverage in dihydrodaidzein and dihydrogenistein

Á Peirotén, P Gaya, JM Landete - Food research international, 2020 - Elsevier
Dihydrodaidzein (DHD) and dihydrogenistein (DHG) are intermediate compounds in the
production of equol and 5-hydroxy-equol from daidzein and genistein by certain intestinal …

Biosynthesis of (−)-5-hydroxy-equol and 5-hydroxy-dehydroequol from soy isoflavone, genistein using microbial whole cell bioconversion

PG Lee, J Kim, EJ Kim, SH Lee, KY Choi… - ACS chemical …, 2017 - ACS Publications
Equols are isoflavandiols formed by reduction of soy isoflavones such as daidzein and
genistein by gut microorganisms. These phytoestrogens are of interest for their various …