Dopaminergic depletion in the nigrostriatal system is the neurochemical hallmark of
Parkinson's disease (PD). Although numerous efforts have been made to determine the …

In mice, the systemical or intracranial application of the neurotoxin 1-methyl-4-phenyl-1, 2, 3,
6-tetrahydropyridine (MPTP) can lead to severe damage to the nigrostriatal dopaminergic …

The classical animal models of Parkinson's disease (PD) rely on the use of neurotoxins,
including 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), 6-hydroxydopamine and …

methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mice model is one of the most common
animal models for Parkinson's disease (PD). It is classified into three types: acute, subacute …

A number of neurotoxin-and gene-based rodent models of acute neurodegeneration of
nigrostriatal dopamine (DA) neurons are used to study Parkinson's disease (PD). The rapid …

The neurotoxicant 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) causes a
Parkinson's disease (PD)-like syndrome by inducing degeneration of nigrostriatal …

Metabolic confusion has been linked to the pathogenesis of Parkinson's disease (PD), while
the dynamic changes associated with the onset and progression of PD remain unclear …

Parkinson's disease (PD) is a common neurodegenerative disorder, resulting from
progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) …

The acute or subacute administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine
(MPTP) has been widely used in C57BL/6 mice to develop models of Parkinson's disease …

Although a valuable 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) animal model of
human Parkinson's disease has been developed, our knowledge of the course of nigral …