Insulin inhibits systemic nonesterified fatty acid (NEFA) flux to a greater degree than glucose
or any other metabolite. This remarkable effect is mainly due to insulin-mediated inhibition of …

Non-esterified fatty acids (NEFA) are the primary energy fuel for most tissues under fasting
conditions. Their release into the circulation results partly from the hydrolysis of …

On this 100 th anniversary of the discovery of insulin, we recognize the critical role that
adipocytes, which are exquisitely responsive to insulin, have played in determining the …

The aim of this review is to summarize the mechanisms underlying insulin resistance in
morbid obesity. Glucose regulation by insulin depends on the suppression of endogenous …

The inhibiting effect of insulin on the mobilization of free fatty acids (FFA) from adipose tissue
is halted in prevalent conditions with systemic insulin resistance. The nature and cause of …

Insulin resistance is often seen as a consequence of obesity and there are several possible
links between adipose tissue function and insulin resistance determined in other organs …

There is now much interest in the mechanisms by which altered lipid metabolism might
contribute to insulin resistance as is found in Syndrome X or in Type II diabetes. This review …

In addition to sc and visceral fat deposits, muscle has been shown to contain relevant
amounts of lipids whose breakdown is subject to hormonal regulation. The aim of the …

It is widely accepted that increasing adiposity is associated with insulin resistance and
increased risk of type 2 diabetes. The predominant paradigm used to explain this link is the …

Insulin is an important regulator of glucose, lipid, and protein metabolism. It suppresses
hepatic glucose and triglyceride production, inhibits adipose tissue lipolysis and whole-body …