Increased mobilization of non-esterified fatty acids (NEFA) from visceral as opposed to
peripheral fat depots can lead to metabolic disturbances because of the direct portal link …

It now appears established that glucose utilization in isolated fat cells prepared from adult ob
ob mice, as well as spontaneosly obese rats, exhibits a markedly impaired responsiveness …

Aims/hypothesis Increased NEFA production and concentrations may underlie insulin
resistance. We examined systemic and adipose tissue NEFA metabolism in insulin-resistant …

In the transition from normal glucose tolerance (NGT) to type 2 diabetes mellitus (T2DM), the
role of β-cell dysfunction and peripheral insulin resistance (IR) is well established. However …

Adipose tissue is a heterogeneous or-gan with respect to embryonic origin, body
distribution, and function. In addition to playing a major role in the regulation of nutrient and …

Elevation of plasma nonesterified fatty acid (NEFA) levels has been shown in various
studies to induce peripheral tissue insulin resistance and impair the suppression of …

Background The accumulation of ectopic fats is related to metabolic syndromes with insulin
resistance, which is considered as the first hit in obesity-related diseases. However …

Aims/hypothesis The aim of this study was to investigate whether intrahepatic and
intramyocellular fat are related to insulin resistance in these respective tissues or to the …

Adipocytes have traditionally been considered to be the primary site for whole body energy
storage mainly in the form of triglycerides and fatty acids. This occurs through the ability of …

Background It is commonly accepted that in obesity free fatty acids (FFA) cause insulin
resistance and hyperglycemia, which drives hyperinsulinemia. However, hyperinsulinemia …