Background Insulin resistance not only occurs in obesity, but also in lipodystrophy. Although
adipose tissue mass affects metabolic fluxes and participates in interorgan crosstalk, the role …

With a positive caloric balance, adipocytes undergo excessive hypertrophy, which causes
adipocyte dysfunction, as well as adipose tissue endocrine and immune responses. A …

To elucidate potential mechanisms for insulin resistance occurring early in the development
of type 2 diabetes, we studied 10 young healthy individuals, each with two first-degree …

Insulin modulates the biochemical pathways controlling lipid uptake, lipolysis and
lipogenesis at multiple levels. Elevated insulin levels are associated with obesity, and …

Despite the well-described association between obesity and insulin resistance, the
physiologic mechanisms that link these two states are poorly understood. The present study …

As a result of selecting triglycerides as the major vehicle for storing superfluous energy,
evolution came up with a specialized cell type, the adipocyte, equipped to handle …

This chapter contains sections titled: Insulin resistance–definitions and role in the natural
history of type 2 diabetes Metabolic syndrome and non‐alcoholic fatty liver disease Insulin …

In adipose tissue, the primary physiological function of insulin is the suppression of lipolysis,
the hydrolysis of stored fat. Mechanistically, insulin suppresses lipolysis both in …

Obesity, the major cause of the current global epidemic of type 2 diabetes (T2D), induces
insulin resistance in peripheral insulin target tissues. Several mechanisms have been …

Adipose tissue metabolism exerts a profound impact on whole-body metabolism. We review
how fuel partitioning between adipocytes and other tissues affects insulin signaling …