Currently, there is no single concept of the optimal spatial structure of mRNA during
translation. It is known that many proteins, associated with the 5'end of mRNA, interact with …

Three models for mRNA translation are discussed in the light of available experimental data.
It is concluded that the elongation rates vary along a messenger, possibly as a result of a …

Messenger RNA (mRNA) secondary structure decreases the elongation rate, as ribosomes
must unwind every structure they encounter during translation. Therefore, the strength of …

Publisher Summary This chapter describes the evidence that differences in the secondary
structures of RNA are probably the main cause of this unpredictability. Although it has been …

The effects of 5'proximal secondary structure in mRNA molecules on their translation and on
their interaction with the eukaryotic initiation factors (eIF)-4F, eIF-4A, and eIF-4B have been …

Eukaryotic gene expression is tightly regulated during translation of mRNA to protein. Mis‐
regulation of translation can lead to aberrant proteins which accumulate in cancers and …

Messenger RNA (mRNA) is no longer considered as a mere informational molecule whose
sole function is to convey the genetic information specified by DNA to the ribosome. Beyond …

During mRNA translation, the genetic information stored in mRNA is translated into a protein
sequence. It is imperative that the genetic information is translated with high precision …

The mechanism of initiation of translation differs between prokaryotes and eukaryotes, and
the strategies used for regulation differ accordingly. Translation in prokaryotes is usually …

Eukaryotic mRNA has a cap structure at the 5′ end and a poly (A) tail at the 3′ end. The
cap and poly (A) tail form a complex with multiple translation factors, and mRNA forms a …