The outcome of patients with T4 esophageal cancer, defined as a tumor that invades
neighboring structures (eg, aorta, trachea, bronchus, and lung), is extremely poor. Despite …

The prognosis of patients with T4 esophageal carcinoma is poor, and thus an effective
treatment needs to be established. The present study assessed the effect of …

Background Survival of patients with cT 4 esophageal cancer is dismal. Although the optimal
treatment strategy remains to be established, two treatment options are available for cT 4 …

Abstract Background and Objectives Multimodal treatment is commonly adopted for patients
with a T4 esophageal cancer. This trial evaluated which therapy offered a better survival …

Esophageal cancer is thought to be the most malignant neoplasm due to its biological
aggressiveness. The most effective treatment modality for esophageal cancer, particularly …

The need for surgery after chemoradiotherapy for a T4N0‐1M0 squamous cell carcinoma in
the thoracic esophagus was evaluated. A series of 53 patients were enrolled in this …

Purpose: Patients with unresectable cT4b esophageal cancer (EC) are rare and largely
excluded from prospective trials. As a result, current treatment recommendations are based …

Background We report the long-term results as primary endpoint in a multicentre
randomized prospective Phase 2 trial which compared chemoradiotherapy (CRT) and triplet …

Objective: This study aimed to determine the long-term survival of patients with cT4
esophageal cancer (EC) and whether neoadjuvant chemoradiotherapy/radiotherapy plus …

Background Treatment of cT4b esophageal carcinoma usually consists of definitive
chemoradiotherapy (dCRT). However, outcome after dCRT in these patients is poor …