Mitochondria are highly dynamic organelles and their distribution, structure and activity
affect a wide range of cellular functions. Mitochondrial membrane potential (∆ Ψm) is an …

Mitochondria are the key regulators of multiple vital cellular processes, including apoptosis,
calcium homeostasis, and the generation of ATP via the metabolic pathway known as …

The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from …

Aging is characterized by a progressive decline in cellular function, organismal fitness and
increased risk of age-associated diseases and death. One potential cause of aging is the …

Mitochondria are eukaryotic organelles known best for their roles in energy production and
metabolism. While often thought of as simply the 'powerhouse of the cell,'these organelles …

Mitochondria are dynamic organelles that continually adapt their structure through fusion
and fission in response to changes in their bioenergetic environment. Targeted deletion of …

Background: Mitochondrial dysfunction has long been considered a major contributor to
aging and age-related diseases. Harman's Mitochondrial Free Radical Theory of Aging …

Studies of human oocytes obtained from women of advanced reproductive age revealed that
spindles are frequently aberrant, with chromosomes sometimes failing to align properly at …

Mitochondria, fundamental organelles in cell metabolism, and ATP synthesis are
responsible for generating reactive oxygen species (ROS), calcium homeostasis, and cell …

Mounting evidence suggests a role for mitochondrial dysfunction in the pathogenesis of
many diseases, including type 2 diabetes, aging, and ovarian failure. Because of the central …