Quantitative in situ PCR assay of HTLV-1 infected cells in peripheral blood lymphocytes of patients with ATL, HAM/TSP and asymptomatic carriers
K Hashimoto, I Higuchi, M Osame, S Izumo - Journal of the neurological …, 1998 - Elsevier
We established an in situ PCR (IS-PCR) method that amplified the pX region of human T cell
lymphotropic virus type 1 (HTLV-1) proviral DNA. The procedure was highly sensitive in …
lymphotropic virus type 1 (HTLV-1) proviral DNA. The procedure was highly sensitive in …
Multiplex real-time PCR for the detection and quantitation of HTLV-1 and HTLV-2 proviral load: addressing the issue of indeterminate HTLV results
A Waters, ALA Oliveira, S Coughlan… - Journal of Clinical …, 2011 - Elsevier
BACKGROUND: Routine diagnosis of Human T Lymphotropic virus (HTLV) infection is
primarily serologically based; however the proportion of unresolved and indeterminate …
primarily serologically based; however the proportion of unresolved and indeterminate …
Do African and European ancestry and polymorphism of HLA class I play an important role in controlling HTLV-1 proviral load in admixed cohorts from Salvador, Brazil …
VN Olavarria, EJ Melo dos Santos… - Retrovirology, 2014 - Springer
HAM/TSP is one of the most prevalent clinical manifestations of HTLV-1 infection, likely
related to high proviral load (PVL). We investigated HLA-A,-B and–C polymorphisms and …
related to high proviral load (PVL). We investigated HLA-A,-B and–C polymorphisms and …
Detection of clinical and neurological signs in apparently asymptomatic HTLV-1 infected carriers: Association with high proviral load
Several studies suggest that HTLV-1 infection may be associated with a wider spectrum of
neurologic manifestations that do not meet diagnostic criteria for HAM/TSP. These …
neurologic manifestations that do not meet diagnostic criteria for HAM/TSP. These …
Human T cell lymphotropic virus type 1 (HTLV‐1) proviral load of HTLV‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new …
MFR Grassi, VN Olavarria… - Journal of medical …, 2011 - Wiley Online Library
A high human T‐cell lymphotropic virus type 1 (HTLV‐1) proviral load is described in HTLV‐
1‐associated diseases, especially HAM/TSP. However, the cut‐off value to define high …
1‐associated diseases, especially HAM/TSP. However, the cut‐off value to define high …
Development and validation of a real-time PCR assay for a novel HTLV-1 tax sequence detection and proviral load quantitation
GM Castro, MC Balangero, E Maturano… - Journal of virological …, 2013 - Elsevier
A quantitative real-time PCR (qPCR) assay using SYBR Green dye was established in order
to detect and quantify the proviral DNA of HTLV-1 in peripheral blood mononuclear cells …
to detect and quantify the proviral DNA of HTLV-1 in peripheral blood mononuclear cells …
HTLV-I proviral load correlates with progression of motor disability in HAM/TSP: analysis of 239 HAM/TSP patients including 64 patients followed up for 10 years
T Matsuzaki, M Nakagawa, M Nagai, K Usuku… - Journal of …, 2001 - Springer
To clarify clinical and laboratory findings that may be related to the pathomechanism of
HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed these …
HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed these …
HAM/TSP in relatives of HAM/TSP cases and in relatives of asymptomatic HTLV-1 carriers
C Alvarez, K Verdonck, M Tipismana, M Talledo… - Retrovirology, 2014 - Springer
To assess the hypothesis that HTLV-1-associated myelopathy/tropical spastic paraparesis
(HAM/TSP) runs in families, we compared the frequency of HAM/TSP among HTLV-1 …
(HAM/TSP) runs in families, we compared the frequency of HAM/TSP among HTLV-1 …
HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the …
K Yasuma, T Matsuzaki, Y Yamano, H Takashima… - Journal of …, 2016 - Springer
Among human T cell leukemia virus type 1 (HTLV-1)-infected individuals, the risk of
developing HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) across …
developing HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) across …
[PDF][PDF] Neurological manifestations in HTLV-1 infected individuals without HAM/TSP: a longitudinal cohort study
D Tanajura, N Castro, P Oliveira, A Neto, A Muniz… - Clin Infect …, 2015 - researchgate.net
Background: Human T cell lymphotropic virus type 1 (HTLV-1) is the agent of HTLV-1
associated myelopathy/tropical spastic paraparesis (HAM/TSP), observed in up to 5% of …
associated myelopathy/tropical spastic paraparesis (HAM/TSP), observed in up to 5% of …