Higher HTLV-1c proviral loads are associated with blood stream infections in an Indigenous Australian population

L Einsiedel, O Cassar, T Spelman, S Joseph… - Journal of clinical …, 2016 - Elsevier
Background An association between blood stream infections (BSI) and HTLV-1
seropositivity in Indigenous Australians might result from HTLV-1 mediated inflammation …

[HTML][HTML] Strong correlation between tax and HBZ mRNA expression in HAM/TSP patients: distinct markers for the neurologic disease

RG Andrade, P de Cássia Gonçalves… - Journal of Clinical …, 2013 - Elsevier
BACKGROUND: HTLV-1 proviral load is a risk marker for HAM/TSP, but it is insufficient to
determine the disease outcome. HTLV-1 Tax and HBZ proteins have been implicated in …

Neurological outcomes analysis of HTLV-1 seropositive patients of the Interdisciplinary Research HTLV Group (GIPH) cohort, Brazil

DB Reiss, GS Freitas, RHC Bastos, MA de Souza… - Retrovirology, 2014 - Springer
HTLV-1 Associated Myelopathy/Tropical spastic paraparesis (HAM/TSP) is the classical
neurological syndrome associated with this retrovirus, although other neurological …

[HTML][HTML] Cytokines, chemokines and leukotrienes profile and signature analysis in HTLV-1 infection as an evidence of disease progression

ALB Starling, DU Gonçalves… - …, 2014 - retrovirology.biomedcentral.com
Background A cross-sectional study evaluated the cytokines, chemokines and leukotrienes
profiles as possible biomarkers of progression to HTLV-1 associated myelopathy (HAM) …

Development and validation of a duplex real-time PCR for the rapid detection and quantitation of HTLV-1

H Ji, L Chang, Y Yan, L Wang - Virology Journal, 2023 - Springer
Background The HTLV-1 prevalence in China varies geographically, while HTLV-2 infection
has rarely been found so far. Proviral load is one of the determining factors of pathogenesis …

Use of synthetic oligonucleotides for determination of HTLV‐1 proviral load by real‐time PCR: a helpful alternative approach in the clinical management

LM Bandeira, MAM Puga, VS de Paula… - Journal of Applied …, 2020 - academic.oup.com
Aims To evaluate the potential use of synthetic oligonucleotides as a standard curve for
proviral load (PVL) of human T‐cell leukaemia virus type 1 (HTLV‐1) quantification in …

Anti-HTLV antibody profiling reveals an antibody signature for HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)

PD Burbelo, E Meoli, HP Leahy, J Graham, K Yao… - Retrovirology, 2008 - Springer
Background HTLV-I is the causal agent of adult T cell leukemia (ATLL) and HTLV-I-
associated myelopathy/tropical spastic paraparesis (HAM/TSP). Biomarkers are needed to …

Immunopathogenesis and treatment of the myelopathy associated to the HTLV-I virus

FJ Carod-Artal - Revista de Neurologia, 2009 - europepmc.org
Conclusions High HTLV-I proviral load and an exaggerated pro-inflammatory cellular
response are involved in the pathogenesis of TSP/HAM. No therapy has been conclusively …

Accumulation of human T-lymphotropic virus type I (HTLV-I)-infected cells in the cerebrospinal fluid during the exacerbation of HTLV-I-associated myelopathy

D Hayashi, R Kubota, N Takenouchi, T Nakamura… - Journal of …, 2008 - Springer
Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is a slowly progressive, inflammatory disease of the central nervous …

In vitro virus propagation and high cellular responsiveness to the infected cells in patients with HTLV-I-associated myelopathy (HAM/TSP)

K Machigashira, S Ijichi, M Nagai, Y Yamano… - Journal of the …, 1997 - Elsevier
The reasons for the development of HTLV-I-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) in certain infected individuals remain poorly understood, but the …