Introduction of newly discovered cardiovascular therapeutics into first-in-man trials depends
on a strictly regulated ethical and legal roadmap. One important prerequisite is a good …

Sustainable and reproducible large animal models that closely replicate the clinical
sequelae of myocardial infarction (MI) are important for the translation of basic science …

Background Preclinical models that resemble the clinical setting as closely as possible are
essential in translating promising therapies for the treatment of acute myocardial infarction …

The development of heart failure is the most powerful predictor of long-term mortality in
patients surviving acute myocardial infarction (MI). There is an unmet clinical need for …

Large animal models of acute myocardial infarction (AMI) play a crucial role in translating
novel therapeutic approaches to patients as denoted by their use in the right-before-human …

Despite enormous efforts in treating myocardial infarction (MI) and subsequent heart failure,
the recent statistics from the American Heart Association evidently show that there still …

Using domestic pigs as an animal model, we here validated a reproducible and
standardized myocardial infarction (MI) surgical model, to achieve the largest possible …

The extent of irreversible loss after an acute myocardial infarction (MI) is still a major
determinant of long-term outcomes. Therefore, strategies to limit MI size are needed [1] …

INTRODUCTION: Progress in cardiovascular regenerative medicine research requires the
availability of appropriate experimental animal models that are as close to humans as …

Establishing an appropriate disease model that mimics the complexities of human
cardiovascular disease is critical for evaluating the clinical efficacy and translation success …