Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …

Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …

Recent genome-wide association scans (GWASs) along with several adequately powered
candidate gene studies have yielded a number of risk alleles for osteoarthritis (OA). This …

Genetic studies have revealed that most loci associated with osteoarthritis (OA) show ethnic
stratification, with limited overlap between Asian and European populations. Consequently …

Osteoarthritis (OA) demonstrates considerable clinical heterogeneity, generating heated
debate over whether OA is a single disease or a complex mix of disparate diseases and …

Osteoarthritis genetic risk predominantly acts by modulating gene expression, an effect
typically mediated via transcriptional regulation. Effects on various pathways have been …

Osteoarthritis (OA) is the most common type of arthritis and no longer is considered as an
absolute consequence of joint mechanical use (wear and tear); rather recent data …

The purpose of this narrative review is to provide an overview of last year's publications in
the field of genetics, genomics and epigenetics in the osteoarthritis (OA) field. Major themes …

Objective In this review, we have highlighted the advances over the past year in genetics,
genomics and epigenetics in the field of osteoarthritis (OA). Methods A literature search of …

Due to initial success in confirming several susceptibility genes and the advent of the post-
genome sequence era, this area of osteoarthritis study is expanding quickly. To overcome …