Cardiovascular diseases, including myocardial infarction and its complications such as heart
failure, are the leading cause of death worldwide. To date, basic and translational research …

The adult mammalian heart has limited endogenous regenerative capacity and heals
through the activation of inflammatory and fibrogenic cascades that ultimately result in the …

Myocardial infarction is the leading cause of death and disability worldwide, and the
development of new treatments can help reduce the size of myocardial infarction and …

Reperfusion therapy has resulted in significant improvement in post-myocardial infarction
morbidity and mortality in over the last 4 decades. Nonetheless, it is well recognized that …

Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …

Unresolved inflammation is a key mediator of advanced heart failure. Especially, damage,
pathogen, and lifestyle-associated molecular patterns are the major factors in initiating …

In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …

Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …

Cardiovascular regenerative therapies are pursued on both basic and translational levels.
Although efficacy and value of cell therapy for myocardial regeneration can be debated …

The limited ability of mammalian adult cardiomyocytes to proliferate following an injury to the
heart, such as myocardial infarction, is a major factor that results in adverse fibrotic and …