Malaria is a serious mosquito-borne disease affecting the majority of Earth's southern
hemisphere. While consistent efforts to curb malaria spread throughout 20th and early 21st …

Virtual ligand screening of a publicly available database of antimalarial hits using a
pharmacophore derived from antimalarial MMV008138 identified TCMDC-140230, a …

The tetrahydro-β-carboline scaffold has proven fertile ground for the discovery of
antimalarial agents (eg, MMV008138 (1) and cipargamin (2)). Similarity searching of a …

Malaria, a disease caused by the parasite Plasmodium, continues to be one of the deadliest
diseases worldwide. The WHO reported over 627,000 deaths in 2020, and over 1 billion …

Malaria is one of the world's most devastating parasitic diseases, causing almost one million
deaths each year. Growing resistance to classical antimalarial drugs, such as chloroquine …

The antimalarial candidate MMV008138 (1a) is of particular interest because its target
enzyme (IspD) is absent in human. To achieve higher potency, and to probe for steric …

Rapid triaging of three series of related hits selected from the Tres Cantos Anti-Malarial Set
(TCAMS) are described. A triazolopyrimidine series was deprioritized due to delayed …

Abstract β-Carboline alkaloids are an eminent class of nitrogen-based natural alkaloids and
therapeutic molecules which exert various pharmacological activities through diverse …

The identification, structure–activity relationships (SARs), and biological effects of new
antimalarials consisting of a 2, 3, 4, 9-tetrahydro-1H-β-carboline core, a coumarin ring, and …

Drug resistance is a major challenge in antimalarial chemotherapy. In addition, a complete
cure of malaria requires intervention at various stages in the development of the parasite …