CD8 epitope escape and reversion in acute HCV infection
J Timm, GM Lauer, DG Kavanagh, I Sheridan… - The Journal of …, 2004 - rupress.org
In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8+ cytotoxic T
lymphocyte (CTL) responses are associated with initial control of viremia. Despite these …
lymphocyte (CTL) responses are associated with initial control of viremia. Despite these …
[PDF][PDF] Selection‐driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection
MJ Fuller, NH Shoukry, T Gushima, DG Bowen… - …, 2010 - Wiley Online Library
Immune escape driven by selection pressure from virus‐specific CD8 T cells has been
demonstrated in both chimpanzees and humans infected with the hepatitis C virus (HCV) …
demonstrated in both chimpanzees and humans infected with the hepatitis C virus (HCV) …
[PDF][PDF] Outcome of acute hepatitis C is related to virus‐specific CD4 function and maturation of antiviral memory CD8 responses
S Urbani, B Amadei, P Fisicaro, D Tola… - …, 2006 - Wiley Online Library
A timely, efficient, and coordinated activation of both CD4 and CD8 T cell subsets following
HCV infection is believed to be essential for HCV control. However, to what extent a failure …
HCV infection is believed to be essential for HCV control. However, to what extent a failure …
[HTML][HTML] Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune response
E Dazert, C Neumann-Haefelin… - The Journal of …, 2009 - Am Soc Clin Investig
There is an association between expression of the MHC class I molecule HLA-B27 and
protection following human infection with either HIV or HCV. In both cases, protection has …
protection following human infection with either HIV or HCV. In both cases, protection has …
[PDF][PDF] Human leukocyte antigen–associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution
J Timm, B Li, MG Daniels, T Bhattacharya… - …, 2007 - Wiley Online Library
CD8+ T cell responses play a key role in governing the outcome of hepatitis C virus (HCV)
infection, and viral evolution enabling escape from these responses may contribute to the …
infection, and viral evolution enabling escape from these responses may contribute to the …
[PDF][PDF] Dominant influence of an HLA‐B27 restricted CD8+ T cell response in mediating HCV clearance and evolution
C Neumann‐Haefelin, S McKiernan, S Ward… - …, 2006 - Wiley Online Library
Virus‐specific CD8+ T cell responses play an important role in the natural course of
infection; however, the impact of certain CD8+ T cell responses in determining clinical …
infection; however, the impact of certain CD8+ T cell responses in determining clinical …
Spontaneous control of HCV is associated with expression of HLA-B* 57 and preservation of targeted epitopes
AY Kim, T Kuntzen, J Timm, BE Nolan, MA Baca… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: HLA class I alleles are linked to spontaneous control of hepatitis C
virus (HCV) and human immunodeficiency virus− 1, but for HCV the roles of particular …
virus (HCV) and human immunodeficiency virus− 1, but for HCV the roles of particular …
[PDF][PDF] CD4+ immune escape and subsequent T‐cell failure following chimpanzee immunization against hepatitis C virus
M Puig, K Mihalik, JC Tilton, O Williams… - …, 2006 - Wiley Online Library
Hepatitis C is a major cause of chronic liver disease, with 170 million individuals infected
worldwide and no available vaccine. We analyzed the effects of an induced T‐cell response …
worldwide and no available vaccine. We analyzed the effects of an induced T‐cell response …
Mutations in immunodominant T cell epitopes derived from the nonstructural 3 protein of hepatitis C virus have the potential for generating escape variants that may …
H Wang, DD Eckels - The Journal of Immunology, 1999 - journals.aai.org
One of the most disturbing features of hepatitis C virus (HCV) is its long-term persistence in
the host. One hypothesis to explain this phenomenon is that HCV escapes immune …
the host. One hypothesis to explain this phenomenon is that HCV escapes immune …
Immune evasion versus recovery after acute hepatitis C virus infection from a shared source
I Tester, S Smyk-Pearson, P Wang… - The Journal of …, 2005 - rupress.org
Acute infection with hepatitis C virus (HCV) rarely is identified, and hence, the determinants
of spontaneous resolution versus chronicity remain incompletely understood. In particular …
of spontaneous resolution versus chronicity remain incompletely understood. In particular …