Sepsis and endotoxemia induce defects in renal tubule function, but the mechanisms are
poorly understood. Recently, we demonstrated that lipopolysaccharide (LPS) inhibits …

Sepsis is associated with defects in renal tubule function, but the underlying mechanisms
are incompletely understood. Recently, we demonstrated that Gram-negative bacterial …

Bacterial infection and sepsis are associated with renal tubule dysfunction and
dysregulation of systemic electrolyte balance but the underlying mechanisms are …

The signal transduction mechanisms that mediate osmotic regulation of Na+/H+ exchange
are not understood. Recently we demonstrated that hyposmolality increases HCO3 …

Renal insufficiency is a common and severe complication of sepsis, and the development of
kidney dysfunction increases morbidity and mortality in septic patients. Sepsis is associated …

Previously we demonstrated that basolateral LPS inhibits HCO 3− absorption in the renal
medullary thick ascending limb (MTAL) through TLR4-dependent ERK activation. Here we …

LPS inhibits HCO 3− absorption in the medullary thick ascending limb (MTAL) through a Toll-
like receptor 4 (TLR4)-myeloid differentiation factor 88 (MyD88)-extracellular signal …

Bacterial infection of the kidney is associated with renal tubule dysfunction and
dysregulation of systemic electrolyte balance. Whether bacterial molecules directly affect …

Sepsis is the leading cause of acute kidney injury in critically ill patients. Tumor necrosis
factor-α (TNF-α) has been implicated in the pathogenesis of septic kidney injury; however …

In the renal medullary thick ascending limb (MTAL), inhibiting the basolateral NHE1 Na+/H+
exchanger with amiloride or nerve growth factor (NGF) results secondarily in inhibition of the …