In the medullary thick ascending limb (MTAL) of rat kidney, inhibiting basolateral Na+/H+
exchange with either amiloride or nerve growth factor (NGF) results secondarily in inhibition …

Although a basolateral Cl−/HCO 3− exchanger (AE) has been implicated in the arginine
vasopressin (AVP)-dependent hypertonic regulatory increase in the medullary thick …

Luminal flow stimulates endogenous nitric oxide (NO) and superoxide (O2−) production by
renal thick ascending limbs (TALs). The delicate balance between these two factors …

In the rat medullary thick ascending limb (MTAL), hyperosmolality inhibits transepithelial
HCO 3− absorption (JHCO 3−) by inhibiting apical membrane Na+/H+ exchange. To …

Collecting duct cells swell when exposed to arginine vasopressin (AVP) in the presence of a
transepithelial osmolality gradient. We investigated the mechanisms of AVP-induced cell …

In the medullary thick ascending limb, inhibiting the basolateral NHE1 Na+/H+ exchanger
with nerve growth factor (NGF) induces actin cytoskeleton remodeling that secondarily …

The thick ascending limb of Henle's loop (TAL) reabsorbs NaCl via the apical Na+-K+-2Cl−
cotransporter (NKCC2). NKCC2 activity is regulated by surface NKCC2 levels. The second …

Luminal flow augments Na+ reabsorption in the thick ascending limb more than can be
explained by increased ion delivery. This segment reabsorbs 30% of the filtered load of Na+ …

Although aldosterone influences a variety of cellular processes through nongenomic
mechanisms, the significance of nongenomic pathways for aldosterone-induced regulation …

Myosin light-chain (MLC) kinase (MLCK)-dependent increase in MLC phosphorylation has
been proposed to be a key mediator of the hyperosmotic activation of the Na+-K+-2Cl …