Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in
ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified …

Abstract Hypoxia-Inducible Factor (HIF)-1 is a dimeric protein complex that plays an integral
role in the body's response to low oxygen concentrations, or hypoxia. HIF-1 is among the …

Angiogenesis is a key enabling feature of mammalian embryonic development and tumor
progression, which provides oxygen and nutrients that are required for vessel growth and …

The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues,
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …

Oxygen availability is crucial for cellular metabolism. Hypoxia-inducible factor 1 (HIF-1) is
the major oxygen homeostasis regulator. Under normoxic conditions, HIF-1 is rapidly …

Hypoxia is a state where oxygen availability/delivery is below the level necessary to
maintain physiological oxygen tension for a particular tissue. It is well-established that when …

Tumor hypoxia is a common feature of many cancers. A master regulator of hypoxic
response is the transcription factor hypoxia-inducible factor-1 (HIF-1). It functions as a …

The growth of new blood vessels from the preexisting vascular tree, also known as
angiogenesis, occurs in situations such as wound and fracture healing, arthritis …

The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular …

Tumor hypoxia was first described in the 1950s by radiation oncologists as a frequent cause
of failure to radiotherapy in solid tumors. Today, it is evident that tumor hypoxia is a common …