Effective vascular regeneration could provide therapeutic benefit for multiple pathologies,
especially in chronic peripheral artery disease (PAD) and myocardial ischemia. The hypoxia …

Most solid tumors develop regions of hypoxia as they grow and outstrip their blood supply. In
order to survive in the stressful hypoxic environment, tumor cells have developed a …

Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic
response in eukaryotic cells, regulating the expression of a myriad of genes involved in …

Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion
distances from the existing vascular supply increases resulting in hypoxia. Sustained …

Hypoxia-inducible factor (HIF) is an α, β-heterodimeric transcription factor that mediates
cellular responses to low oxygen concentration via the transcriptional activation of specific …

The α/β-heterodimeric transcription factor hypoxia-inducible factor (HIF) functions when the
oxygen level in tissues is low, ie when the tissue microenvironment becomes hypoxic, and is …

Localized tissue hypoxia is a consequence of vascular compromise or rapid cellular
proliferation and is a potent inducer of compensatory angiogenesis. The oxygen-responsive …

An understanding of underlying mechanisms involved in the activation of HIF‐1 in response
to both hypoxic stress and oncogenic signals has important implications for how these …

Abstract Hypoxia-inducible factor 1 (HIF-1) mediates transcriptional responses to hypoxia.
HIF-1 is composed of an O2-and growth factor-regulated HIF-loc subunit and a constitutively …

The mechanisms that regulate angiogenesis in hypoxia or hypoxic microenvironment are
modulated by several pro-and antiangiogenic factors. Hypoxia-inducible factors (HIFs) have …