Emerging evidence indicates that myeloid cells are essential for promoting new blood
vessel formation by secreting various angiogenic factors. Given that hypoxia-inducible factor …

Abstract Hypoxia‐inducible factor (HIF)‐1 and HIF‐2 are heterodimeric transcription factors
that mediate the cellular response to hypoxia. Their key regulatory subunits, HIF‐1α and HIF …

The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor 1) represents the key
mediator of hypoxia response. HIF-1 controls numerous genes of pivotal importance for …

Simple Summary Accumulating evidence indicates that hypoxia-inducible factor-1 (HIF-1)
plays a pivotal role in tumor biology, particularly in hypoxic environments. Over the past few …

Hypoxia-inducible factor-1 (HIF-1) regulates the transcription of many genes induced by low
oxygen conditions. Recent studies have demonstrated that non-hypoxic stimuli can also …

Hypoxia‐inducible transcription factors (HIF) mediate complex adaptations to reduced
oxygen supply, including neoangiogenesis. Regulation of HIF occurs mainly through oxygen …

Abstract The hypoxia‐inducible factor‐1 (HIF‐1) is an oxygen‐regulated transcriptional
activator playing a pivotal role in mammalian physiology and disease pathogenesis, eg, HIF …

Hypoxia is a major event that occurs in most solid tumors. Intratumoral hypoxia is sufficient to
activate the key transcription factor, hypoxia-inducible factor (HIF) that mediates the …

Hypoxic up-regulation of hypoxia-inducible factors (HIFs) during tumourigenesis presents an
interesting paradox with respect to their role in tumour growth. Hypoxia-inducible factor 1 …

Hypoxia, the decline of tissue oxygen stress, plays a role in mediating cellular processes.
Cardiovascular disease, relatively widespread with increased mortality, is closely correlated …