Background—Accumulating evidence suggests a critical role for increased reactive oxygen
species (ROS) production in left ventricular (LV) remodeling and dysfunction after …

Oxidative stress is a hallmark of systemic illnesses, including heart failure. Nevertheless, the
overall importance of radical production in the heart remains conjectural; is it merely a …

Aims Oxidative stress, ie imbalance between reactive oxygen species (ROS) and antioxidant
defences, contributes to the progression of chronic heart failure (CHF). Acute inhibition of …

Objectives: This study sought to ascertain if high-dose allopurinol regresses left ventricular
mass (LVM) in patients with ischemic heart disease (IHD). Background: LV hypertrophy …

Myocardial oxidative stress and Ca2+ overload induced by ischemia-reperfusion may be
involved in the development and progression of myocardial dysfunction in heart failure …

It has been reported that the xanthine oxidase inhibitor, allopurinol, has a protective effect on
ischemia–reperfusion injury, but the precise mechanism of its action is still unclear …

Increased reactive oxygen species (ROS) generation is implicated in cardiac remodeling in
heart failure (HF). As xanthine oxidoreductase (XOR) is 1 of the major sources of ROS, we …

Allopurinol reduces formation of cytotoxic free radicals during myocardial
ischemia/reperfusion in animals. To evaluate the effect of allopurinol on cardiac …

Objectives: This study sought to ascertain whether high-dose allopurinol causes regression
of left ventricular mass (LVM) in patients with type 2 diabetes mellitus (T2DM). Background …

After myocardial infarction, ventricular geometry and function, as well as energy metabolism,
change markedly. In nonischemic heart failure, inhibition of xanthine oxidase (XO) improves …