Ischemic strokes cause devastating brain damage and functional deficits with few treatments
available. Previous studies have shown that the ischemia-hypoxia rapidly induces clinically …

To understand and potentially treat the lifelong cognitive and motor deficits in humans
resulting from perinatal mild cerebral hypoxic–ischemic (HI) events, valid animal models are …

Rodent models of stroke are often used to investigate the mechanisms that lead to ischemic
neuronal damage. In this study, we used a model of cerebral hypoxia with ischemia to …

Hypoxia is a critical factor for cell death or survival in ischemic stroke, but the pathological
consequences of combined ischemia-hypoxia are not fully understood. Here we examine …

C57BL/6J are the most commonly used strain of mouse for stroke experiments but vascular
anatomy of the Circle of Willis within this strain is extremely variable and the cortex has …

We performed unilateral carotid artery occlusion on CD-1 mice to create a neonatal hypoxic-
ischemic (HI) model and investigated the effects of neonatal HI brain injury by studying …

Ischemic tolerance induced by hyperoxia (HO) can protect against brain injury and
neurodegenerative diseases. Although multiple studies demonstrate neuroprotection by HO …

Ischemic stroke (IS) induces neurological damage due to cerebrovascular occlusion.
Restoring blood perfusion to the ischemic brain area in a timely fashion is the most effective …

Background: Chronic cerebral hypoperfusion (CCH) is associated with neurological
changes and cognitive decline. It is a major cause of vascular dementia and a contributing …

The treatment and prevention of hypoxic/ischemic brain injury in stroke patients remain a
severe and global medical issue. Numerous clinical studies have resulted in a failure to …