Cells have developed numerous adaptation mechanisms to external cues by controlling
signaling-pathway activity, both qualitatively and quantitatively. The Wnt/β-catenin pathway …

Abstract β‐catenin mediates Wnt signaling by acting as the essential co‐activator for TCF
transcription factors. Wnt signaling increases the half‐life and therefore the absolute level of …

Wnt signaling orchestrates gene expression via its effector, β-catenin. However, it is
unknown whether β-catenin binds its target genomic regions simultaneously and how this …

Wnt signaling refers to a conserved signaling pathway, widely studied due to its roles in
cellular communication, cell fate decisions, development and cancer. However, the exact …

WNT/β-catenin signaling is crucial to all stages of life. It controls early morphogenetic events
in embryos, maintains stem cell niches in adults, and is dysregulated in many types of …

Wnt/β-catenin signaling plays a major role in embryonic development and adult stem cell
maintenance. Reduced activation of the Wnt/β-catenin pathway underlies …

Signal propagation from the cell membrane to a promoter can induce gene expression. To
examine signal transmission through sub-cellular compartments and its effect on …

Wnt/β-catenin signaling is activated repeatedly during an animal's lifespan, and it controls
gene expression through its essential nuclear effector, β-catenin, to regulate …

The Protein Kinase A (PKA) and Wnt signaling cascades are fundamental pathways
involved in cellular development and maintenance. In the osteoblast lineage, these …

β-Catenin not only regulates cell to cell adhesion as a protein interacting with cadherin, but
also functions as a component of the Wnt signaling pathway. The Wnt signaling pathway is …