A promising approach in cancer therapy is the inhibition of cell proliferation using small
molecules. In this study, we report the synthesis of suramin derivatives and their …

The inhibition of protein function by small compounds plays a critical role in controlling cell
proliferation. We report on a new class of small molecule (NCTU-Alan-2026) inhibitors for …

The design, synthesis, and biological evaluation of a series of pyrrole and pyrazole
congeners 2 of suramin, directed toward the development and identification of new ligands …

As a popular drug, suramin has attracted much attention for a century. It has an extensive
record of clinical trials. This review article gives a brief introduction of its wide biological …

Some heterocyclic analogs of suramin with potent and selective basic fibroblast growth
factor (bFGF) complexing activity have been synthesized. The possible mode of action of …

The extracellular portion of the human fibroblast growth factor receptor2 D2 domain (FGFR2
D2) interacts with human fibroblast growth factor 1 (hFGF1) to activate a downstream …

Suramin has shown promising antitumour activity against several tumour types, both in vitro
and in vivo, but the clinical utility of this compound is hampered by its unfavourable toxicity …

Radiotherapy is the principal therapy for nasopharyngeal carcinoma (NPC) at early stages.
A number of chemotherapeutic methods have been used to inhibit the progression of NPC at …

ADVANCES IN molecular biology and the concept of autocrine-stimulated tumor growth
have provided many novel targets for cancer therapy. Suramin may be regarded as the …

Suramin is a polysulfonated naphthylurea with demonstrable activity against cancer of the
prostate. While its precise mechanism of antitumor activity is uncertain, it is likely to be …