The basal forebrain cholinergic system (BFCS) has long been implicated in age-related
cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of …

Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary financial and emotional burdens (Apostolova …

Down syndrome (DS, trisomy 21) is characterized by intellectual impairment at birth and
Alzheimer's disease (AD) pathology in middle age. As individuals with DS age, their …

Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …

The basal forebrain cholinergic neurons (BFCN) provide the primary source of cholinergic
innervation of the human cerebral cortex. They are involved in the cognitive processes of …

The basal forebrain cholinergic system (BFCS) is known to undergo moderate
neurodegenerative alterations during normal aging and severe atrophy in Alzheimer's …

Evidence suggests that the basal forebrain (BF) cholinergic system degenerates early in the
course of Alzheimer's disease (AD), likely due to the vulnerability of BF cholinergic neurons …

The major populations of cholinergic neurons in the brain include two “projection” systems,
located in the pontine reticular formation and in the basal forebrain. These two complexes …

The cholinergic neurons of the basal forebrain (BF) provide virtually all of the brain's cortical
and amygdalar cholinergic input. They are particularly vulnerable to neuropathology in early …

The basal forebrain cholinergic complex comprising medial septum, horizontal and vertical
diagonal band of Broca, and nucleus basalis of Meynert provides the mayor cholinergic …