Signal-induced transcriptional programs regulate critical biological processes through the
precise spatiotemporal activation of Immediate Early Genes (IEGs); however, the …

The transition of RNA polymerase II (Pol II) from transcription initiation into productive
elongation in eukaryotic cells is regulated by the P-TEFb kinase, which phosphorylates the …

Precise control of the RNA polymerase II (RNA Pol II) cycle, including pausing and pause
release, maintains transcriptional homeostasis and organismal functions. Despite previous …

Gene transcription occurs via a cycle of linked events including initiation, promoter proximal
pausing and elongation of RNA polymerase II (Pol II). A key question is how do …

Promoter-proximal pausing of RNA polymerase II (Pol II) is a major checkpoint in
transcription. An unbiased search for new human proteins that could regulate paused Pol II …

The transition from transcription initiation to elongation at promoters of primary response
genes (PRGs) in metazoan cells is controlled by inducible transcription factors, which utilize …

Gene expression is tightly controlled by Cyclin-dependent kinases (CDKs) which regulate
the RNA Polymerase II (RNAPII) transcription cycle at discrete checkpoints. RNAPII pausing …

Understanding the complex network and dynamics that regulate transcription elongation
requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of …

ABSTRACT RNA polymerase II (Pol II) pausing at promoter-proximal regions is a highly
regulated step in the transcription cycle. Pause release is facilitated by the P-TEFb kinase …

Cyclin-dependent kinase 12 (CDK12) interacts with cyclin K to form a functional nuclear
kinase that promotes processive transcription elongation through phosphorylation of the C …