Most human genes are loaded with promoter-proximally paused RNA polymerase II (Pol II)
molecules that are poised for release into productive elongation by P-TEFb. We present …

Elongation is becoming increasingly recognized as a critical step in eukaryotic
transcriptional regulation. Although traditional genetic and biochemical studies have …

Eukaryotic protein‐coding genes are typically classified into two groups: those with
expression regulated by specific signals versus the relatively constant “housekeeping” …

Summary RNA polymerase II (RNAPII) pausing in early elongation is critical for gene
regulation. Paused RNAPII can be released into productive elongation by the kinase P-TEFb …

Although traditionally viewed as universal stretches of DNA, core promoters are diverse
regulatory sequences with a high impact on transcriptional activity in promoters and …

Many canonical signaling pathways exhibit complex time-varying responses, yet how
minutes-timescale pulses of signaling interact with the dynamics of transcription and gene …

Modifications of histones are intricately linked with the regulation of gene expression, with
demonstrated roles in various physiological processes and disease pathogenesis …

Cap-dependent translation drives the global synthesis of proteins. Under stress conditions
global protein production is attenuated, yet the translation of ATF4 is upregulated through …

The vast majority of eukaryotic transcription occurs in bursts during discrete periods of
promoter activity, separated by periods of deep repression and inactivity. Elucidating the …

The MAPK pathway is an important cellular signaling cascade whose dysregulation causes
a variety of diseases. While the upstream regulators of this cascade have been extensively …