Cathelicidin peptides restrict bacterial growth via membrane perturbation and induction of reactive oxygen species

DA Rowe-Magnus, AY Kao, AC Prieto, M Pu, C Kao - MBio, 2019 - Am Soc Microbiol
All metazoans produce antimicrobial peptides (AMPs) that have both broad antimicrobial
and immunomodulatory activity. Cathelicidins are AMPs that preferentially kill Gram …

[HTML][HTML] Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity

B Ramanathan, EG Davis, CR Ross, F Blecha - Microbes and infection, 2002 - Elsevier
Antimicrobial peptides are important host-defense molecules of innate immunity.
Cathelicidins are a diverse family of potent, rapidly acting and broadly effective antimicrobial …

Endogenous cathelicidin production limits inflammation and protective immunity to Mycobacterium avium in mice

JC Santos, S Silva‐Gomes, JP Silva… - Immunity …, 2014 - Wiley Online Library
The production of antimicrobial peptides, such as the cathelicidins, plays a prominent role in
the innate immune response against microbial pathogens. Cathelicidins are widely …

[HTML][HTML] Systemic Responses of Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Following Exposure to the Antimicrobial Peptide …

C Liu, B Shan, J Qi, Y Ma - Frontiers in Cellular and Infection …, 2017 - frontiersin.org
Cathelicidin-BF, derived from the banded krait (Bungarus fasciatus), is a typically cationic,
amphiphilic and α-helical antimicrobial peptide (AMP) with 30 amino acids that exerts …

Expression of an additional cathelicidin antimicrobial peptide protects against bacterial skin infection

PHA Lee, T Ohtake, M Zaiou… - Proceedings of the …, 2005 - National Acad Sciences
Cathelicidin antimicrobial peptides are effectors of innate immune defense in mammals.
Humans and mice have only one cathelicidin gene, whereas domesticated mammals such …

Role of cathelicidin peptides in bovine host defense and healing

L Tomasinsig, M Benincasa, M Scocchi… - Probiotics and …, 2010 - Springer
The in vitro antimicrobial activities and biological effects on host cells were compared for the
bovine cathelicidins BMAP-28, an alpha-helical AMP, and Bac5 and Bac7, proline-rich …

[HTML][HTML] Imaging the antimicrobial mechanism (s) of cathelicidin-2

VAF Schneider, M Coorens, SR Ordonez… - Scientific reports, 2016 - nature.com
Host defence peptides (HDPs) have the potential to become alternatives to conventional
antibiotics in human and veterinary medicine. The HDP chicken cathelicidin-2 (CATH-2) has …

Cathelicidin antimicrobial peptides with reduced activation of toll-like receptor signaling have potent bactericidal activity against colistin-resistant bacteria

C Kao, X Lin, G Yi, Y Zhang, DA Rowe-Magnus, K Bush - MBio, 2016 - Am Soc Microbiol
The world is at the precipice of a postantibiotic era in which medical procedures and minor
injuries can result in bacterial infections that are no longer effectively treated by antibiotics …

Cathelicidins, essential gene-encoded mammalian antibiotics

M Zaiou, RL Gallo - Journal of molecular medicine, 2002 - Springer
Cathelicidins are a class of gene-encoded antibiotics found exclusively in mammals. In vitro
and in vivo studies indicate they are effector molecules of mammalian innate immunity that …

[HTML][HTML] Diversity, antimicrobial action and structure-activity relationship of buffalo cathelicidins

B Brahma, MC Patra, S Karri, M Chopra, P Mishra… - PLoS …, 2015 - journals.plos.org
Cathelicidins are an ancient class of antimicrobial peptides (AMPs) with broad spectrum
bactericidal activities. In this study, we investigated the diversity and biological activity of …