Uncoordinated clashes between replication forks and transcription cause replication stress
and genome instability, which are hallmarks of cancer and neurodegeneration. Here, we …

Transcription hinders replication fork progression and stability. The ATR checkpoint and
specialized DNA helicases assist DNA synthesis across transcription units to protect …

The yeast RNA/DNA helicase Sen1, Senataxin in human, preserves the integrity of
replication forks encountering transcription by removing RNA-DNA hybrids. Here we show …

Replication stress (RS) is a leading cause of genome instability and cancer development. A
substantial source of endogenous RS originates from the encounter between the …

Replication and transcription are key aspects of DNA metabolism that take place on the
same template and potentially interfere with each other. Conflicts between these two …

DNA replication and RNA transcription compete for the same substrate during S phase.
Cells have evolved several mechanisms to minimize such conflicts. Here, we identify the …

RNA: DNA hybrids form when nascent transcripts anneal to the DNA template strand or any
homologous DNA region. Co-transcriptional RNA: DNA hybrids, organized in R-loop …

An important but still enigmatic function of DNA: RNA hybrids is their role in DNA double-
strand break (DSB) repair. Here, we show that Sen1, the budding yeast ortholog of the …

DNA replication preferentially initiates close to active transcription start sites (TSSs) in the
human genome. Transcription proceeds discontinuously with an accumulation of RNA …

Cellular homeostasis requires the coordination of several machineries concurrently
engaged in the DNA. Wide-spread transcription can interfere with other processes, and …