[PDF][PDF] Protective effect of resveratrol on knee osteoarthritis and its molecular mechanisms: a recent review in preclinical and clinical trials

S Yang, M Sun, X Zhang - Frontiers in Pharmacology, 2022 - frontiersin.org
Osteoarthritis (OA) is one of the progressing chronic joint associated with by many complex
factors such as age, obesity, and trauma. Knee osteoarthritis (KOA) is the most common type …

Resveratrol suppresses interleukin-1β-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the …

M Shakibaei, C Csaki, S Nebrich… - Biochemical pharmacology, 2008 - Elsevier
Osteoarthritis is an inflammatory disease of load-bearing synovial joints that is currently
treated with drugs that exhibit numerous side effects and are only temporarily effective on …

[HTML][HTML] Resveratrol, potential therapeutic interest in joint disorders: a critical narrative review

C Nguyen, JF Savouret, M Widerak, MT Corvol… - Nutrients, 2017 - mdpi.com
Trans-resveratrol (t-Res) is a natural compound of a family of hydroxystilbenes found in a
variety of spermatophyte plants. Because of its effects on lipids and arachidonic acid …

Effect of resveratrol on serum levels of type II collagen and aggrecan in patients with knee osteoarthritis: a pilot clinical study

BH Marouf - BioMed Research International, 2021 - Wiley Online Library
Treatment of knee osteoarthritis (OA) remains a challenging concern. Preclinical studies
provided accumulating evidence on resveratrol efficacy in ameliorating degenerative …

A comprehensive insight into effects of resveratrol on molecular mechanism in rheumatoid arthritis: a literature systematic review

A Karimi, PS Azar, M Kadkhodayi… - International Journal …, 2022 - Wiley Online Library
Aim Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, which is
characterized by massive pain and destruction of synovial joints, leads to bone erosion …

[HTML][HTML] Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis

Y Wei, J Jia, X Jin, W Tong… - Molecular medicine …, 2018 - spandidos-publications.com
Resveratrol is a non‑flavonoid polyphenol compound with a stilbene structure. As a type of
phytoalexin produced under stress in plants, it improves the plant's resistance against …

[HTML][HTML] Resveratrol alleviates the interleukin-1β-induced chondrocytes injury through the NF-κB signaling pathway

H Yi, W Zhang, ZM Cui, SY Cui, JB Fan, XH Zhu… - Journal of Orthopaedic …, 2020 - Springer
Background Osteoarthritis (OA) is a regular age-related disease that affects millions of
people. Resveratrol (RSV) is a flavonoid with a stilbene structure with different …

Resveratrol, a natural antioxidant, protects monosodium iodoacetate-induced osteoarthritic pain in rats

ZM Wang, YC Chen, DP Wang - Biomedicine & Pharmacotherapy, 2016 - Elsevier
Background Osteoarthritis (OA) is a chronic progressive joint disease characterized by
advanced joint pain, subchondral bone sclerosis and articular cartilage degeneration …

Resveratrol alleviates rheumatoid arthritis via reducing ROS and inflammation, inhibiting MAPK signaling pathways, and suppressing angiogenesis

G Yang, CC Chang, Y Yang, L Yuan, L Xu… - Journal of agricultural …, 2018 - ACS Publications
Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting joints and is
featured by chronic synovial inflammation and angiogenesis. We employed a bovine type-II …

[HTML][HTML] Protective effect of resveratrol against IL-1β-induced inflammatory response on human osteoarthritic chondrocytes partly via the TLR4/MyD88/NF-κB signaling …

L Liu, H Gu, H Liu, Y Jiao, K Li, Y Zhao, L An… - International journal of …, 2014 - mdpi.com
Resveratrol is a natural polyphenolic compound that prevents inflammation in chondrocytes
and animal models of osteoarthritis (OA) via yet to be defined mechanisms. The purpose of …