Isodeoxyelephantopin, a sesquiterpene lactone induces ROS generation, suppresses NF-κB activation, modulates LncRNA expression and exhibit activities against …

SS Verma, V Rai, N Awasthee, A Dhasmana… - Scientific reports, 2019 - nature.com
The sesquiterpene lactones, Isodeoxyelephantopin (IDET) and Deoxyelephantopin (DET)
are known to exhibit activities against some cancer types. The activities of these lactones …

[HTML][HTML] Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death

JY Shiau, K Nakagawa-Goto, KH Lee, LF Shyur - Oncotarget, 2017 - ncbi.nlm.nih.gov
Triple negative breast cancer (TNBC) is a highly metastatic cancer among the breast cancer
subgroups. A thorny issue for clinical therapy of TNBC is lack of an efficient targeted …

[HTML][HTML] Deoxyelephantopin, a novel naturally occurring phytochemical impairs growth, induces G2/M arrest, ROS-mediated apoptosis and modulates lncRNA …

V Pandey, A Tripathi, A Rani, PK Dubey - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Abstract Deoxyelephantopin (DOE), a phytochemical, extracted and purified from
Elephantopus scaber, has been shown to exhibit antitumor activities. Objective of the …

[HTML][HTML] Novel sesquiterpene lactone analogues as potent anti-breast cancer agents

K Nakagawa-Goto, JY Chen, YT Cheng, WL Lee… - Molecular …, 2016 - Elsevier
Triple-negative breast cancer (TNBC) is associated with high grade, metastatic phenotype,
younger patient age, and poor prognosis. The discovery of an effective anti-TNBC agent has …

Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells through reactive oxygen species-mediated mitochondrion-dependent pathway

L Cui, W Bu, J Song, L Feng, T Xu, D Liu… - Archives of pharmacal …, 2018 - Springer
Alantolactone is a sesquiterpene lactone isolated from Inula helenium L. Although
alantolactone possesses anti-inflammation and apoptosis-induction activities, the underlying …

6-O-Angeloylenolin induces apoptosis through a mitochondrial/caspase and NF-κB pathway in human leukemia HL60 cells

L ChangLong, W HeZhen, H YongPing… - Biomedicine & …, 2008 - Elsevier
6-O-Angeloylenolin, a sesquiterpene lactone from Centipeda minima, has been known to
have anti-tumor activity against human colorectum, liver, stomach, lung, and skin tumor cells …

Oleuropein induces apoptosis via abrogating NF‐κB activation cascade in estrogen receptor–negative breast cancer cells

L Liu, KS Ahn, MK Shanmugam, H Wang… - Journal of cellular …, 2019 - Wiley Online Library
Oleuropein is one of the most abundant phenolic compounds found in olives.
Epidemiological studies have indicated that an increasing intake of olive oil can significantly …

Deoxyelephantopin induces apoptosis in HepG2 cells via oxidative stress, NF‐κB inhibition and mitochondrial dysfunction

T Mehmood, A Maryam, H Zhang, Y Li, M Khan… - Biofactors, 2017 - Wiley Online Library
Deoxyelephantopin (DET), a naturally occurring sesquiterpene lactone present in Chinese
medicinal herb, Elephantopus scaber has been shown to exert anti‐inflammatory as well as …

Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation

X Zhang, X Wang, T Wu, B Li, T Liu, R Wang, Q Liu… - Scientific Reports, 2015 - nature.com
Isoliensinine, liensinine and neferine are major bisbenzylisoquinoline alkaloids in the seed
embryo of lotus (Nelumbo nucifera) and exhibit potential anti-cancer activity. Here, we …

Potential Metabolite Nymphayol Isolated from Water Lily (Nymphaea stellata) Flower Inhibits MCF-7 Human Breast Cancer Cell Growth via Upregulation of Cdkn2a …

LN Al-Harbi, P Subash-Babu, MA Binobead… - Metabolites, 2020 - mdpi.com
Controlled production of cyclin dependent kinases (CDK) and stabilization of tumor
suppressor genes are the most important factors involved in preventing carcinogenesis. The …