The advent of interstitial chemotherapy has significantly increased therapeutic options for
patients with malignant glioma. Interstitial chemotherapy can deliver high concentrations of …

In this review, the authors summarize the key findings in some of the most important clinical
studies of locally administered treatments for malignant glioma. A few such therapies have …

New approaches to malignant glioma are being actively investigated. Local drug delivery
directly to the site of the tumor is one novel approach that has been approved by the US FDA …

Malignancies of the central nervous system represent a formidable challenge and prognosis
of patients remains dismal. Physiological barriers impede efficacious delivery of tumoricidal …

Systemic chemotherapy of malignant brain tumors has failed to achieve sufficient drug
concentrations at the neoplasm site and frequently results in severe toxicities. Therefore, the …

Malignant gliomas are the most frequently occurring, devastating primary brain tumors, and
are coupled with a poor survival rate. Despite the fact that complete neurosurgical resection …

Malignant gliomas are very difficult neoplasms for clinicians to treat. The reason for this is
multifaceted. Many treatments that are effective for systemic cancer are unable to cross the …

Glioma is the most common form of primary brain tumor, as well as the most lethal. Primary
treatment strategies for glioma, including cytoreductive surgery, external-beam irradiation …

Introduction: Glioblastoma multiforme (GBM) is the most prevalent primary neoplasm of the
brain. Moreover, the prognosis of patients with GBM has been poor, with almost uniform …

Malignant gliomas, including glioblastoma and anaplastic astrocytomas, are characterized
by their propensity to invade surrounding brain parenchyma, making curative resection …