Transcription termination occurs when a transcribing RNA polymerase releases the DNA
template and the nascent RNA. Termination is required for preventing the inappropriate …

During transcription termination by RNA polymerase II on protein-coding genes, the nuclear
5′ exonuclease Rat1/Xrn2 degrades the nascent transcript downstream from the …

The Saccharomyces cerevisiae SEN1 gene codes for a nuclear-localized superfamily I
helicase. SEN1 is an ortholog of human SETX (senataxin), which has been implicated in the …

Transcriptome‐wide interrogation of eukaryotic genomes has unveiled the pervasive nature
of RNA polymerase II transcription. Virtually, any DNA region with an accessible chromatin …

Termination of RNA polymerase II (RNAPII) transcription is a fundamental step of gene
expression that involves the release of the nascent transcript and dissociation of RNAPII …

Transcription termination of protein-coding genes in eukaryotic cells usually relies on a tight
coordination between the cleavage and polyadenylation of the pre-mRNA, and 5′-3 …

Pervasive transcription of eukaryotic genomes stems to a large extent from bidirectional
promoters that synthesize mRNA and divergent noncoding RNA (ncRNA). Here, we show …

Long non-coding RNA (lncRNA) transcription into a downstream promoter frequently results
in transcriptional interference. However, the mechanism of this repression is not fully …

Cryptic unstable transcripts (CUTs) are synthesized from intra-and intergenic regions in
Saccharomyces cerevisiae and are rapidly degraded by RNA surveillance pathways, but …

We have recently demonstrated that an mRNA capping enzyme, Cet1, impairs promoter-
proximal accumulation/pausing of RNA polymerase II (Pol II) independently of its capping …