Effect of growth hormone on insulin signaling

R Sharma, JJ Kopchick, V Puri, VM Sharma - Molecular and cellular …, 2020 - Elsevier
Growth hormone (GH) is a pleiotropic hormone that coordinates an array of physiological
processes, including effects on bone, muscle, and fat, ultimately resulting in growth …

The effects of growth hormone on adipose tissue: old observations, new mechanisms

JJ Kopchick, DE Berryman, V Puri, KY Lee… - Nature Reviews …, 2020 - nature.com
The ability of growth hormone (GH) to induce adipose tissue lipolysis has been known for
over five decades; however, the molecular mechanisms that mediate this effect and the …

Growth hormone acts along the PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes

VM Sharma, ET Vestergaard… - American Journal …, 2019 - journals.physiology.org
The lipolytic effects of growth hormone (GH) have been known for half a century and play an
important physiological role for substrate metabolism during fasting. In addition, sustained …

Biological effects of growth hormone on carbohydrate and lipid metabolism

A Vijayakumar, R Novosyadlyy, YJ Wu, S Yakar… - Growth Hormone & IGF …, 2010 - Elsevier
This review will summarize the metabolic effects of growth hormone (GH) on the adipose
tissue, liver, and skeletal muscle with focus on lipid and carbohydrate metabolism. The …

Pharmacological antilipolysis restores insulin sensitivity during growth hormone exposure

S Nielsen, N Møller, JS Christiansen… - Diabetes, 2001 - Am Diabetes Assoc
Stimulation of lipolysis and the induction of resistance to insulin's actions on glucose
metabolism are well-recognized effects of growth hormone (GH). To evaluate whether these …

Growth Hormone Signaling in Vivo in Human Muscle and Adipose Tissue: Impact of Insulin, Substrate Background, and Growth Hormone Receptor Blockade

C Nielsen, LC Gormsen, N Jessen… - The Journal of …, 2008 - academic.oup.com
Context: GH induces insulin resistance in muscle and fat, and in vitro data indicate that this
may involve cross-talk between the signaling pathways of the two hormones. Objective: Our …

The intricate role of growth hormone in metabolism

A Vijayakumar, S Yakar, D LeRoith - Frontiers in endocrinology, 2011 - frontiersin.org
Growth hormone (GH), a master regulator of somatic growth, also regulates carbohydrate
and lipid metabolism via complex interactions with insulin and insulin-like growth factor-1 …

Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects

N Møller, JOL Jørgensen - Endocrine reviews, 2009 - academic.oup.com
In evolutionary terms, GH and intracellular STAT 5 signaling is a very old regulatory system.
Whereas insulin dominates periprandially, GH may be viewed as the primary anabolic …

[PDF][PDF] Impact of growth hormone on regulation of adipose tissue

KM Troike, BE Henry, EA Jensen, JA Young… - Compr …, 2017 - researchgate.net
Increasing prevalence of obesity and obesity-related conditions worldwide has necessitated
a more thorough understanding of adipose tissue (AT) and expanded the scope of research …

Growth hormone and adipose tissue: beyond the adipocyte

DE Berryman, EO List, L Sackmann-Sala… - Growth Hormone & IGF …, 2011 - Elsevier
The last two decades have seen resurgence in research focused on adipose tissue. In part,
the enhanced interest stems from an alarming increase in obesity rates worldwide. However …