The aim of these studies was to establish a rapid in vivo assay for evaluating potential
“cocaine antagonists,” ie, drugs postulated to block cocaine binding to the dopamine …

Recent evidence enriches our understanding of the molecular sites of action of cocaine
reward and locomotor stimulation. Dopamine transporter blockade by cocaine appears a …

Cocaine's blockade of dopamine reuptake by brain dopamine transporters (DAT) is a central
feature of current understanding of cocaine reward and addiction. Empirical screening of …

Although the dopamine transporter (DAT) is the primary site of action for cocaine, and the
dopamine system is known to mediate the reinforcing effects of cocaine, the dopaminergic …

Cocaine elevates dopamine (DA) in the nucleus accumbens (NAc) by blocking the uptake of
DA through the DA transporter (DAT). It is commonly believed that the reinforcing properties …

Repeated exposure to cocaine produces changes in the nervous system that facilitate drug‐
seeking behaviors. These drug‐seeking behaviors have been studied with animal models …

Cocaine conditioned place preference (CPP) is intact in dopamine transporter (DAT)
knockout (KO) mice and enhanced in serotonin transporter (SERT) KO mice. However …

Drug addiction involves compulsive drug-seeking and drug-taking despite known adverse
consequences. The enduring nature of drug addiction suggests that repeated exposure to …

Cocaine-induced increases in dopamine signaling in nucleus accumbens (NAc) play a
significant role in cocaine seeking behavior. The majority of cocaine addiction research has …

Abstract Outbred male Sprague–Dawley rats can be classified as either low or high cocaine
responders (LCRs or HCRs, respectively) based on their locomotor response to acute …