Introduction There is an ever-increasing range of antibiotic-resistant pathogens that have led
to higher community-acquired infections, and substantial mortality rates in critically ill …

Inappropriate antimicrobial therapy of pneumonia, severe sepsis and bacteraemia is
associated with high mortality. Adjustment of insufficient initial antibiotics after susceptibility …

The antibiotic pipeline continues to diminish and the majority of the public remains unaware
of this critical situation. The cause of the decline of antibiotic development is multifactorial …

Antimicrobial treatment is the cornerstone of infection treatment, and the selection of
appropriate antibiotic treatment for critically ill patients is challenging. Clinicians working …

Optimal and responsible use of antibiotics : Current Opinion in Critical Care Optimal and
responsible use of antibiotics : Current Opinion in Critical Care Log in or Register Subscribe to …

Appropriate antibiotic therapy in patients with severe sepsis and septic shock should mean
prompt achievement and maintenance of optimal exposure at the infection site with broad …

Introduction: The altered pathophysiology in critically ill patients presents a unique
challenge in both the diagnosis of infection and the appropriate prescription of antibiotics. In …

Sepsis affects approximately 750,000 individuals in the United States each year, accounting
for 2.1% to 4.3% of hospitalizations, and 11% of all admissions to the ICU. 1 From 1979 to …

In the management of a patient with severe sepsis, it is important to suspect the infection
early, to collect samples immediately after diagnosis and to promptly initiate a broad …

The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …