Radiation therapy is the most effective cytotoxic therapy for localized tumors. However,
normal tissue toxicity limits the radiation dose and the curative potential of radiation therapy …

Purpose Preclinical studies using ultra-high dose rate (FLASH) irradiation have
demonstrated reduced normal tissue toxicity compared with conventional dose rate (CONV) …

Methods We developed a preclinical FLASH irradiation system for mice using a clinical
linear accelerator. To produce extremely high dose rates over the field of interest, we (1) …

In vitro studies suggested that sub-millisecond pulses of radiation elicit less genomic
instability than continuous, protracted irradiation at the same total dose. To determine the …

Background Ultrahigh dose‐rate irradiation (FLASH‐IR) was reported to be efficient in tumor
control while reducing normal tissue radiotoxicity. However, the mechanism of such …

Different from conventional radiotherapy (CONV-RT), FLASH radiotherapy (FLASH-RT)
delivers a single high dose at a mean dose rate≥ 40​ Gy/s in milliseconds to achieve …

DNA-damaging treatments such as radiotherapy (RT) have become promising to improve
the efficacy of immune checkpoint inhibitors by enhancing tumor immunogenicity. However …

Recent reports have shown that very high dose rate radiation (35–100 Gy/second) referred
to as FLASH tends to spare the normal tissues while retaining the therapeutic effect on …

A novel irradiation platform using a proton beam leads to an improved therapeutic window
through sparing of normal tissue toxicity. Preliminary experiments suggest involvement of …

Definition Flash radiotherapy (Flash-RT) is an innovative technique used in radiotherapy for
cancer treatment because it delivers an extremely high dose of radiation (> 40 Gy/s) to the …