Dependence on the 26S proteasome is an Achilles' heel for triple-negative breast cancer
(TNBC) and multiple myeloma (MM). The therapeutic proteasome inhibitor, bortezomib …

Ever since the ubiquitin proteasome system was characterized, efforts have been made to
manipulate its function to abrogate the progression of cancer. As a result, the anti-cancer …

The epithelial-mesenchymal transition (EMT) endows carcinoma cells with phenotypic
plasticity that can facilitate the formation of cancer stem cells (CSCs) and contribute to the …

Curcumin, the active ingredient in Curcuma longa, has been in medicinal use since ancient
times. However, the therapeutic targets and signaling cascades modulated by curcumin …

The use of proteasome inhibitors to target cancer's dependence on altered protein
homeostasis has been greatly limited by intrinsic and acquired resistance. Analyzing data …

Proteasomes play a critical role in the fate of proteins that are involved in major cellular
processes, including signal transduction, gene expression, cell cycle, replication …

Cancer cells show heightened dependency on the proteasome for their survival, growth, and
spread. Proteasome dysregulation is therefore commonly selected in favor of the …

Despite the fundamental importance of proteasomal degradation in cells, little is known
about whether and how the 26S proteasome itself is regulated in coordination with various …

Protein degradation by the ubiquitin–proteasome system (UPS) is central to protein
homeostasis and cell survival. The active 26S proteasome is a large protease complex …

The proteasome is clinically validated as a target for cancer therapeutics. However,
proteasome-inhibitory agents that are cancer selective have yet to be developed. In this …