Objectives Intraplaque angiogenesis and inflammation are key promoters of atherosclerosis
and are mediated by the alpha-V beta-3 (αvβ3) integrin pathway. We investigated the …

Background Inflammation and angiogenesis play an important role in atherosclerotic plaque
rupture. Therefore, molecular imaging of these processes could be used for determination of …

Objective Maladaptive repair contributes towards the development of heart failure following
myocardial infarction (MI). The αvβ3 integrin receptor is a key mediator and determinant of …

Background Expression of α v β 3 integrin has been proposed as a marker for
atherosclerotic lesion inflammation. We studied whether diet intervention reduces uptake of …

Background α V β 3-integrin is expressed by activated endothelial cells and macrophages in
atherosclerotic plaques and may represent a valuable marker of high-risk plaques. We …

Objectives: The goal of this study was to evaluate the feasibility of [18F] Galacto-RGD
positron emission tomography (PET)/computed tomography (CT) imaging of αvβ3 …

Background Integrin alpha-V-beta-3 (αvβ3) pathway is involved in intraplaque angiogenesis
and inflammation and represents a promising target for molecular imaging in cardiovascular …

Introduction Rupture of unstable atherosclerotic plaque that leads to stroke and myocardial
infarction may be induced by macrophage infiltration and neovessel formation. A tracer that …

Purpose A newly developed synthetic αvβ3 integrin targeted optical probe (ITOP) has been
demonstrated to target cancer cells, in vivo. Compared to the commercially available cyclic …

Aims The purpose of this study was to determine the feasibility of a new positron emission
tomography (PET) imaging approach using an 18F-labelled αvβ3 integrin antagonist (18F …