A clinical approach to children with C3 glomerulopathy

M Vivarelli, N van de Kar, R Labbadia… - Pediatric …, 2022 - Springer
C3 glomerulopathy is a relatively new clinical entity that represents a challenge both to
diagnose and to treat. As new therapeutic agents that act as complement inhibitors become …

[HTML][HTML] Overview of C3 glomerulopathy

V Master Sankar Raj, R Gordillo, DH Chand - Frontiers in pediatrics, 2016 - frontiersin.org
C3 glomerulopathy is an umbrella term, which includes several rare forms of
glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A …

C3 Glomerulopathy

M Riedl, P Thorner, C Licht - Pediatric Nephrology, 2017 - Springer
Recent advances in our understanding of the disease pathology of membranoproliferative
glomerulonephritis has resulted in its re-classification as complement C3 glomerulopathy …

Evolution of immunoglobulin deposition in C3-dominant membranoproliferative glomerulopathy

E Kerns, D Rozansky, ML Troxell - Pediatric Nephrology, 2013 - Springer
Abstract Background Complement 3 glomerulopathy (C3GN) is a newly proposed
subcategory of glomerular disease with features including membranoproliferative …

Treatment of C3 glomerulopathy with complement blockers

M Vivarelli, F Emma - Seminars in thrombosis and hemostasis, 2014 - thieme-connect.com
C3 glomerulopathy (C3G) is a newly defined clinical entity comprising glomerular lesions
with predominant C3 staining. Under this definition are now included membranoproliferative …

[PDF][PDF] Diagnosis and treatment of C3 glomerulopathy in a center of expertise

JJE Koopman, YKO Teng, CJF Boon… - Neth J Med, 2019 - njmonline.nl
ABSTRACT C3 glomerulopathy is a rare renal disease that has been distinguished as a
renal disease for about 10 years. It is caused by an excessive activation of the alternative …

Update on C3 glomerulopathy: a complement-mediated disease

F Caravaca-Fontán, L Lucientes, T Cavero, M Praga - Nephron, 2020 - karger.com
Abstract C3 glomerulopathy (C3G) is a clinicopathologic entity secondary to dysregulation of
the alternative complement pathway in plasma and the glomerular microenvironment. The …

[HTML][HTML] C3 glomerulopathy: what's in a name?

VD D'Agati, AS Bomback - Kidney international, 2012 - Elsevier
Whereas early classifications of membranoproliferative glomerulonephritis (MPGN) were
based on morphologic features, the modern approach is directed at immunofluorescence …

Complement C3-targeted therapy in C3 glomerulopathy, a prototype of complement-mediated kidney diseases

MS Meuleman, A Grunenwald, S Chauvet - Seminars in Immunology, 2022 - Elsevier
Abstract C3 glomerulopathy (C3G) is a rare and complex kidney disease that primarily
affects young adults. Renal outcomes remain poor in the absence of specific treatment. C3G …

Autoimmune abnormalities of the alternative complement pathway in membranoproliferative glomerulonephritis and C3 glomerulopathy

M Noris, R Donadelli, G Remuzzi - Pediatric Nephrology, 2019 - Springer
Membranoproliferative glomerulonephritis (MPGN) is a rare chronic kidney disease
associated with complement activation. Recent immunofluorescence-based classification …