It has been proposed that binge eating reflects a pathological compulsion driven by the
“addictive” properties of foods. Proponents of this argument highlight the large degree of …

Significant sleep impairments often accompany substance use disorders (SUDs). Sleep
disturbances in SUD patients are associated with poor clinical outcomes and treatment …

Orexin plays a significant role in the modulation of REM sleep, as well as in the regulation of
appetite and feeding. This review explores, first, the current evidence on the role of orexin in …

Although originally implicated in appetite and sleep/wakefulness, the hypothalamic orexin
(hypocretin) system has now been demonstrably linked with motivated behavior. This highly …

▪ Abstract Orexin-A and orexin-B are neuropeptides originally identified as endogenous
ligands for two orphan G-protein–coupled receptors. Orexin neuropeptides (also known as …

Recent studies have implicated the orexin system as a critical regulator of sleep/wake states
as well as feeding behavior and reward processes. Orexin deficiency results in narcolepsy …

The finding of orexin (hypocretin) deficiency in patients with narcolepsy suggests that this
hypothalamic neuropeptide plays a crucial role in regulating and maintaining …

The neuropeptides orexin A and orexin B, produced in hypothalamic neurons, are critical
regulators of sleep/wake states. Deficiency of orexin signaling results in narcoleptic …

Recent studies have implicated the orexin system as a critical regulator of sleep/wake states,
feeding behavior, and reward processes. Orexin deficiency results in narcolepsy-cataplexy …

The tight regulation of sleep/wake states is critical for mental and physiological wellbeing.
For example, dysregulation of sleep/wake systems predisposes individuals to metabolic …