Background: Diabetic nephropathy (DN) has become one of the most common causes of
end stage renal disease (ESRD). Hyperglycemia induces oxidative stress in renal tubular …

Objective: Diabetes mellitus associated structural alterations are considered as early
adaptive shifts and are associated with progression of nephropathy. Structural changes may …

Objectives Diabetic nephropathy (DN) is the leading cause of end-stage renal disease
worldwide. The NO system has been implicated in the pathogenesis of DN. In this study, we …

Introduction: little is known about the potential effects induced by sulphonylureas
independently of their anti-hyperglycemic action. The present study examined the effect of …

Aim: To further reveal the effects of leflunomide on renal protection and on inflammatory
response using streptozotocin (STZ) induced diabetic rats. Methods: Male Wistar rats were …

Objective: This study aims to evaluate the effects of pioglitazone hydrochloride (PIO) on the
expression of renal nephrin and explore its possible reno-protective mechanism in …

We studied the effects of streptozotocin (STZ)-induced diabetes on kidney morphology,
anatomy, architecture and on the activities of aminotransferases (AST and ALT), alkaline …

Nephropathy is one of the complications of diabetes mellitus in human and experimental
animals. There are various pathological renal remodeling processes leading to diabetic …

Objective (s): Hyperglycemia promotes oxidative stress that plays a crucial role in the
pathogenesis of Diabetic nephropathy (DN). In this study, we investigated the synergism …

Background While there is an evidence that the anti-inflammatory properties of
spironolactone can attenuate proteinuria in type 2 diabetes, its effects on vascular …