Nucleus Basalis Stimulation Enhances Working Memory by Stabilizing Attractor Networks in Prefrontal Cortex

XL Qi, R Liu, B Singh, D Bestue, A Compte… - bioRxiv, 2019 - biorxiv.org
Acetylcholine in the neocortex is critical for executive function. Degeneration of the basal
forebrain cholinergic system is associated with cognitive decline in aging and Alzheimer's …

[PDF][PDF] Nucleus basalis stimulation stabilizes attractor networks and enhances task representation in prefrontal cortex

XL Qi, R Liu, AI Vazdarjanova, DT Blake… - BioRxiv, 2019 - scholar.archive.org
The action of acetylcholine in the neocortex is critical for executive function. Cholinergic
drugs can improve cognitive function in patient populations and normal adults. How …

Nucleus basalis stimulation enhances working memory by stabilizing stimulus representations in primate prefrontal cortical activity

XL Qi, R Liu, B Singh, D Bestue, A Compte… - Cell reports, 2021 - cell.com
Acetylcholine plays a critical role in the neocortex. Cholinergic agonists and
acetylcholinesterase inhibitors can enhance cognitive functioning, as does intermittent …

Behavioral Investigations of Deep Brain Stimulation of the Basal Forebrain and its Application to Alzheimer's Disease Treatment

C Christos - 認知神経科学, 2019 - jstage.jst.go.jp
Cognitive functions such as working memory and selective attention depend on the action of
neuromodulators in the cerebral cortex, including acetylcholine. Drugs that act on the …

Cholinergic neuromodulation of prefrontal attractor dynamics controls performance in spatial working memory

A Mahrach, D Bestue, XL Qi… - Journal of …, 2024 - Soc Neuroscience
The behavioral and neural effects of the endogenous release of acetylcholine following
stimulation of the nucleus basalis (NB) of Meynert have been recently examined in two male …

Improving visual working memory with cholinergic deep brain stimulation

JM Bava, Z Wang, SK Bick, DJ Englot, C Constantinidis - Brain Sciences, 2023 - mdpi.com
Acetylcholine is a critical modulatory neurotransmitter for cognitive function. Cholinergic
drugs improve cognitive performance and enhance neuronal activity in the sensory and …

Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer's disease models

SK Power, S Venkatesan, S Qu, JA McLaurin… - bioRxiv, 2023 - biorxiv.org
Background Cognitive reserve allows for resilience to neuropathology, potentially through
active compensation. Here, we examine electrophysiological evidence for active …

Potential for intermittent stimulation of nucleus basalis of Meynert to impact treatment of alzheimer's disease

DT Blake, AV Terry, M Plagenhoef… - … & integrative biology, 2017 - Taylor & Francis
The brain's cholinergic arousal pathways decline in parallel with the brain's executive
functions in aging and Alzheimer's Disease. The frontline and currently most effective …

Cholinergic modulation of working memory activity in primate prefrontal cortex

X Zhou, XL Qi, K Douglas… - Journal of …, 2011 - journals.physiology.org
The prefrontal cortex, a cortical area essential for working memory and higher cognitive
functions, is modulated by a number of neurotransmitter systems, including acetylcholine; …

Rhythmicity of prefrontal local field potentials after nucleus basalis stimulation

B Singh, XL Qi, DT Blake, C Constantinidis - Eneuro, 2022 - eneuro.org
The action of acetylcholine in the cortex is critical for cognitive functions and cholinergic
drugs can improve functions such as attention and working memory. An alternative means of …