Intraventricular hemorrhage and white matter injury in preclinical and clinical studies

O Romantsik, M Bruschettini, D Ley - Neoreviews, 2019 - publications.aap.org
Germinal matrix–intraventricular hemorrhage (IVH) occurs in nearly half of infants born at
less than 26 weeks' gestation. Up to 50% of survivors with IVH develop cerebral palsy …

Cerebral gray matter injuries in infants with intraventricular hemorrhage

DR Sharma, A Agyemang, P Ballabh - Seminars in perinatology, 2022 - Elsevier
While intraventricular hemorrhage (IVH) predominantly damages the periventricular white
matter, it induces substantial injury to the cerebral gray matter. IVH destroys the germinal …

White matter injury in infants with intraventricular haemorrhage: mechanisms and therapies

P Ballabh, LS de Vries - Nature Reviews Neurology, 2021 - nature.com
Intraventricular haemorrhage (IVH) continues to be a major complication of prematurity that
can result in cerebral palsy and cognitive impairment in survivors. No optimal therapy exists …

Recovery of the brain after intraventricular hemorrhage

B Cheng, P Ballabh - Seminars in Fetal and Neonatal Medicine, 2022 - Elsevier
Intraventricular hemorrhage (IVH) remains a major complication of prematurity, worldwide.
The severity of IVH is variable, ranging from a tiny germinal matrix bleed to a moderate-to …

Characterization of acute brain injuries and neurobehavioral profiles in a rabbit model of germinal matrix hemorrhage

P Georgiadis, H Xu, C Chua, F Hu, L Collins, C Huynh… - Stroke, 2008 - Am Heart Assoc
Background and Purpose—Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-
IVH) is the most common neurological problem of premature infants and has enormous …

Cognitive impairment and brain and peripheral alterations in a murine model of intraventricular hemorrhage in the preterm newborn

A Segado-Arenas, C Infante-Garcia… - Molecular …, 2018 - Springer
Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) remains a serious
complication in the preterm newborn. The significant increase of survival rates in extremelye …

Acute brain inflammation, white matter oxidative stress, and myelin deficiency in a model of neonatal intraventricular hemorrhage

DS Goulding, RC Vogel, JC Gensel… - Journal of …, 2020 - thejns.org
OBJECTIVE Neonatal intraventricular hemorrhage (IVH) leads to posthemorrhagic
hydrocephalus (PHH), brain injury, and long-term disability. Current therapy for IVH is based …

Preterm intraventricular hemorrhage/posthemorrhagic hydrocephalus

TE Inder, JM Perlman, JJ Volpe - Volpe's Neurology of the Newborn, 2025 - Elsevier
Germinal matrix–intraventricular hemorrhage (GMH-IVH) is the most common variety of
neonatal intracranial hemorrhage and is characteristic of the premature infant. This form of …

Intraventricular hemorrhage: severity factor and treatment target in spontaneous intracerebral hemorrhage

DF Hanley - Stroke, 2009 - Am Heart Assoc
Background and Purpose—This review focuses on the emerging principles of intracerebral
hemorrhage (ICH) management, emphasizing the natural history and treatment of …

Severe intraventricular hemorrhage causes long-lasting structural damage in a preterm rabbit pup model

O Romantsik, E Ross-Munro, S Grönlund… - Pediatric …, 2022 - nature.com
Background Intraventricular hemorrhage causes significant lifelong mortality and morbidity,
especially in preterm born infants. Progress in finding an effective therapy is stymied by a …