Therapeutic potential of neurotrophic factors in Alzheimer's Disease

A Nasrolahi, F Javaherforooshzadeh… - Molecular biology …, 2022 - Springer
Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the
most common cause of dementia among the elderly population. AD is accompanied with the …

Transgenic mice with chronic NGF deprivation and Alzheimer's disease-like pathology display hippocampal region-specific impairments in short-and long-term …

G Houeland, A Romani, C Marchetti… - Journal of …, 2010 - Soc Neuroscience
The etiology of Alzheimer's disease (AD) remains elusive. The “amyloid” hypothesis states
that toxic action of accumulated β-amyloid peptide (Aβ) on synaptic function causes AD …

Blood–brain barrier penetrating biologic TNF-α inhibitor for Alzheimer's disease

R Chang, J Knox, J Chang… - Molecular …, 2017 - ACS Publications
Tumor necrosis factor alpha (TNF-α) driven processes are involved at multiple stages of
Alzheimer's disease (AD) pathophysiology and disease progression. Biologic TNF-α …

Treadmill exercise ameliorates spatial learning and memory deficits through improving the clearance of peripheral and central amyloid-beta levels

D Khodadadi, R Gharakhanlou, N Naghdi… - Neurochemical …, 2018 - Springer
Aggregated amyloid beta (Aβ) peptides are believed to play a decisive role in the pathology
of Alzheimer's disease (AD). Previous evidence suggested that exercise contributes to the …

Effects of TNFα-converting enzyme inhibition on amyloid β production and APP processing in vitro and in vivo

ML Kim, B Zhang, IP Mills, ME Milla… - Journal of …, 2008 - Soc Neuroscience
Tumor necrosis factor-α (TNFα) is a proinflammatory cytokine that is elevated in Alzheimer's
disease (AD) brains. Because TNFα is released from cell membranes by the TNFα …

Impact of an additional chronic BDNF reduction on learning performance in an Alzheimer mouse model

L Psotta, C Rockahr, M Gruss, E Kirches… - Frontiers in behavioral …, 2015 - frontiersin.org
There is increasing evidence that brain-derived neurotrophic factor (BDNF) plays a crucial
role in Alzheimer's disease (AD) pathology. A number of studies demonstrated that AD …

Nobiletin restoring β-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats

K Matsuzaki, T Yamakuni, M Hashimoto, AM Haque… - Neuroscience …, 2006 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive and memory deterioration. Production and accumulation of β-amyloid peptide (Aβ) …

Low levels of brain-derived neurotrophic factor trigger self-aggregated amyloid β-induced neuronal cell death in an Alzheimer's cell model

N Tagai, A Tanaka, A Sato, F Uchiumi… - Biological and …, 2020 - jstage.jst.go.jp
Alzheimer's disease (AD) is pathologically characterized by accumulation of amyloid β (Aβ)
and hyperphosphorylated tau, and thereby induction of neuronal cell death. The Aβ-induced …

Neuroprotective effect of fisetin against amyloid-beta-induced cognitive/synaptic dysfunction, neuroinflammation, and neurodegeneration in adult mice

A Ahmad, T Ali, HY Park, H Badshah, SU Rehman… - Molecular …, 2017 - Springer
Alzheimer's disease (AD) is a devastating and progressive neurodegenerative disease and
is characterized pathologically by the accumulation of amyloid beta (Aβ) and the …

Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel

HM Al-Kuraishy, MS Jabir, AI Al-Gareeb… - Ageing Research …, 2023 - Elsevier
In Alzheimer disease (AD), amyloid precursor protein (APP) and production of amyloid beta
(Aβ) which is generated by amyloidogenic pathway is implicated in neurotoxicity and …